Rabbit anti-Human, Mouse TBX15/TBX18 Polyclonal Antibody | anti-TBX15/TBX18 antibody

TBX15/TBX18 Antibody

Cat. Num. AAA7132746

• Gene Names: TBX15; TBX14
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: TBX15/TBX18; Polyclonal Antibody; TBX15/TBX18 Antibody; T-box Transcription factor TBX15; T-box protein 15; TBX15; TBX14; T-box Transcription factor TBX18; anti-TBX15/TBX18 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; Rabbit IgG In Phosphate Buffered Saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.

• Applicable Applications for anti-TBX15/TBX18 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:3000; IHC: 1:50-1:100; IF: 1:100-1:500
• Immunogen: Synthesized peptide derived from internal of human TBX15/18.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blot analysis of extracts from HeLa cells, HUVEC cells and Jurkat cells, using TBX15/18 antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using TBX15/18 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of HeLa cells, using TBX15/18 antibody.)

Product Categories/Family for anti-TBX15/TBX18 antibody

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 55770860
• NCBI GeneID: 6913
• NCBI Accession #: NP_689593.2
• NCBI GenBank Nucleotide #: NM_152380.2
• UniProt Accession #: Q96SF7; O95935
• Molecular Weight: 54,671 Da
• NCBI Official Full Name: T-box transcription factor TBX15
• NCBI Official Synonym Full Names: T-box 15
• NCBI Official Symbol: TBX15
• NCBI Official Synonym Symbols: TBX14
• NCBI Protein Information: T-box transcription factor TBX15; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14
• UniProt Protein Name: T-box transcription factor TBX15
• UniProt Gene Name: TBX15
• UniProt Synonym Gene Names: TBX14; T-box protein 15; T-box protein 14
• UniProt Entry Name: TBX15_HUMAN

NCBI Description

This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009]

Uniprot Description

TBX15: Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes. Defects in TBX15 are the cause of Cousin syndrome (COUSS); also known as craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature. Cousin syndrome is defined as pelviscapular dysplasia with epiphyseal abnormalities, congenital dwarfism and facial dysmorphy (frontal bossing, hypertelorism, narrow palpebral fissures, deep set globes, strabismus, low-set posteriory rotated and unusually formed external ears, dysplasia of conchae, small chin, short neck with redundant skin folds, and a low hairline). Intelligence may vary from normal to moderately impaired. Radiographic features comprise aplasia of the body of the scapula, hypoplasia of the iliac bone, humeroradial synosthosis, dislocation of the femoral heads, and moderate brachydactyly. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1p11.1

Molecular Function: protein homodimerization activity; protein heterodimerization activity; transcription factor activity

Biological Process: transcription, DNA-dependent; embryonic cranial skeleton morphogenesis; negative regulation of transcription from RNA polymerase II promoter

Disease: Cousin Syndrome