Western Blot (WB)
(Western Blot (WB) analysis of TBC1D2 polyclonal antibody at 1:500 dilutionLane1:MCF-7 whole cell lysateLane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate)
Rabbit TBC1D2 Polyclonal Antibody | anti-TBC1D2 antibody
TBC1D2 Polyclonal Antibody
Gene Names
TBC1D2; PARIS1; PARIS-1; TBC1D2A
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
TBC1D2; Polyclonal Antibody; TBC1D2 Polyclonal Antibody; TBC1 domain family member 2A; Armus; Prostate antigen recognized and identified by SEREX 1; PARIS-1; BC1D2; PARIS1; PP8997; TBC1D2A; anti-TBC1D2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
TBC1D2 polyclonal antibody detects endogenous levels of TBC1D2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
468
Applicable Applications for anti-TBC1D2 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:1000
Immunogen
A synthetic peptide corresponding to residues in Human TBC1D2.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot (WB) analysis of TBC1D2 polyclonal antibody at 1:500 dilutionLane1:MCF-7 whole cell lysateLane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate)
Western Blot (WB)
(Western Blot (WB) analysis of TBC1D2 polyclonal antibody at 1:500 dilutionLane1:MCF-7 whole cell lysateLane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate)
Related Product Information for anti-TBC1D2 antibody
GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. TBC1D2 (TBC1 domain family member 2), also known as Armus or PARIS-1 (prostate antigen recognized and identified by SEREX 1), is a 928 amino acid protein containing a Rab-GAP TBC domain and a PH domain. Localizing to cytoplasm, cytoplasmic vesicles and cell junctions, TBC1D2 is expressed in a broad range of tissues, including kidney, liver, lung and placenta, as well as in keratinocytes and epithelia-containing organs. TBC1D2 functions as a GTPase-activating protein for RAB7, and also acts as a linker between RAB7 and RAC1, which leads to RAB7A inactivation and inhibition of E-cadherin degradation. Existing as six alternatively spliced isoforms, the gene encoding TBC1D2 maps to human chromosome 9q22.33.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 105kDa
NCBI Official Full Name
TBC1 domain family member 2A isoform 3
NCBI Official Synonym Full Names
TBC1 domain family member 2
NCBI Official Symbol
TBC1D2
NCBI Official Synonym Symbols
PARIS1; PARIS-1; TBC1D2A
NCBI Protein Information
TBC1 domain family member 2A
UniProt Protein Name
TBC1 domain family member 2A
Protein Family
UniProt Gene Name
TBC1D2
UniProt Synonym Gene Names
PARIS1; PP8997; TBC1D2A; PARIS-1
UniProt Entry Name
TBD2A_HUMAN
Uniprot Description
TBC1D2: a putative GTPase activating protein for Rab family protein(s). Expressed in a broad range of tissues. Differentially expressed in prostate normal and cancer cells.
Protein type: GAPs, Rab; GAPs
Chromosomal Location of Human Ortholog: 9q22.33
Cellular Component: cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; cell junction
Molecular Function: protein binding; cadherin binding
Research Articles on TBC1D2
Similar Products
Product Notes
The TBC1D2 tbc1d2 (Catalog #AAA3007078) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TBC1D2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TBC1D2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the TBC1D2 tbc1d2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TBC1D2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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