Goat TBC1D10A Polyclonal Antibody | anti-TBC1D10A antibody

Goat Polyclonal to Human TBC1D10A

Cat. Num. AAA246709

• Gene Names: TBC1D10A; EPI64; TBC1D10; dJ130H16.1; dJ130H16.2
• Reactivity: Human, Monkey; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: TBC1D10A; Polyclonal Antibody; Goat Polyclonal to Human TBC1D10A; Anti-TBC1D10A Antibody (aa2-14) IHC-plus; AC004997.C22.2; DJ130H16.1; EBP50-PDZ interactor of 64 kD; DJ130H16.2; EPI64 protein; EBP50-PDX interactor of 64 kDa; EPI64; TBC1 domain family member 10A; TBC1 domain family; member 10A; Rab27A-GAP-alpha; member 10; TBC1D10; Human TBC1D10A; anti-TBC1D10A antibody

• Host: Goat
• Reactivity: Human, Monkey; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human TBC1D10A.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 508

• Applicable Applications for anti-TBC1D10A antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (4.75 - 10 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide AKSNGENGPRAPA-C from positions 2-14 of human TBC1D10A (NP_114143.1). Percent identity by BLAST analysis: Human, Marmoset (100%); Gibbon (92%); Mouse, Rat, Bovine, Pig (85%).
• Immunogen Type: Synthetic peptide
• Immunogen: TBC1D10A antibody was raised against synthetic peptide AKSNGENGPRAPA-C from positions 2-14 of human TBC1D10A (NP_114143.1). Percent identity by BLAST analysis: Human, Marmoset (100%); Gibbon (92%); Mouse, Rat, Bovine, Pig (85%).
• Antigen Modification: aa2-14
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-TBC1D10A antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-TBC1D10A antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4.75 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 13994322
• NCBI GeneID: 83874
• NCBI Accession #: NP_114143.1
• NCBI GenBank Nucleotide #: NM_031937.2
• UniProt Accession #: Q9BXI6; O76053; Q20WK7; Q543A2; B3KXT8
• Molecular Weight: 57,935 Da
• NCBI Official Full Name: TBC1 domain family member 10A isoform 2
• NCBI Official Synonym Full Names: TBC1 domain family, member 10A
• NCBI Official Symbol: TBC1D10A
• NCBI Official Synonym Symbols: EPI64; TBC1D10; dJ130H16.1; dJ130H16.2
• NCBI Protein Information: TBC1 domain family member 10A; rab27A-GAP-alpha; EBP50-PDZ interactor of 64 kD; EBP50-PDX interactor of 64 kDa
• UniProt Protein Name: TBC1 domain family member 10A
• Protein Family: TBC1 domain family
• UniProt Gene Name: TBC1D10A
• UniProt Synonym Gene Names: EPI64; TBC1D10; EPI64 protein
• UniProt Entry Name: TB10A_HUMAN

Uniprot Description

TBC1D10A: a GTPase-activating protein (GAP) for RAB27A, but not for RAB2A, RAB3A, nor RAB4A. Binds to the first PDZ domain of SLC9A3R1 and SLC9A3R2. Localizes to the microvilli-rich region of the syncytiotrophoblast. In melanocytes, located at the periphery of cells.

Protein type: GAPs, Rab; GAPs

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: microvillus; plasma membrane

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; PDZ domain binding

Biological Process: positive regulation of proteolysis; retrograde transport, endosome to Golgi