Western Blot (WB)
(TAF6 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TAF6 antibody detected the TAF6 protein (arrow).)
Rabbit TAF6 Polyclonal Antibody | anti-TAF6 antibody
TAF6 Antibody (N-term)
Western Blot (WB)
(TAF6 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TAF6 antibody detected the TAF6 protein (arrow).)
Western Blot (WB)
(TAF6 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TAF6 antibody detected the TAF6 protein (arrow).)
the activities of more than 70 polypeptides. The protein that
coordinates these activities is transcription factor IID (TFIID),
which binds to the core promoter to position the polymerase
properly, serves as the scaffold for assembly of the remainder of
the transcription complex, and acts as a channel for regulatory
signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated
factors or TAFs. TAFs may participate in basal transcription, serve
as coactivators, function in promoter recognition or modify general
transcription factors (GTFs) to facilitate complex assembly and
transcription initiation. This gene encodes one of the smaller
subunits of TFIID that binds weakly to TBP but strongly to TAF1,
the largest subunit of TFIID. Alternative splicing results in
multiple transcript variants.
Wilhelm, E., et al. BMC Mol. Biol. 11, 10 (2010) :
Wilhelm, E., et al. PLoS ONE 3 (7), E2721 (2008) :
Frontini, M., et al. Mol. Cell. Biol. 25(11):4638-4649(2005)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
NCBI and Uniprot Product Information
NCBI Description
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Uniprot Description
TAF6: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Belongs to the TAF6 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription initiation complex
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: nucleoplasm; transcription factor TFIID complex; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; protein heterodimerization activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; negative regulation of cell proliferation; viral reproduction; regulation of transcription factor activity; regulation of transcription, DNA-dependent; transcription initiation; RNA elongation from RNA polymerase II promoter; gene expression; negative regulation of cell cycle
Research Articles on TAF6
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Product Notes
The TAF6 taf6 (Catalog #AAA9205618) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 24-53. The TAF6 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's TAF6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the TAF6 taf6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TAF6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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