Rabbit TAF5L Polyclonal Antibody | anti-TAF5L antibody

TAF5L (E323) Polyclonal Antibody

Cat. Num. AAA3002650

• Gene Names: TAF5L; PAF65B
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TAF5L; Polyclonal Antibody; TAF5L (E323) Polyclonal Antibody; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; PCAF-associated factor 65 beta; PAF65-beta; PAF65B; anti-TAF5L antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TAF5L (E323) polyclonal antibody detects endogenous levels of TAF5L protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 325

• Applicable Applications for anti-TAF5L antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 301-350 of Human TAF5L.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of TAF5L (E323) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.)

Related Product Information for anti-TAF5L antibody

TAF5L (TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L), also known as PAF65B, is a 589 amino acid protein that localizes to the nucleus and contains six WD repeats. Existing as a component of the PCAF histone acetylase complex, TAF5L interacts with a number of TAFs and, via this interaction, plays a role in histone acetylation and transcription initiation. Defects in the gene encoding TAF5L, which is expressed as multiple alternatively spliced isoforms, are associated with the pathogenesis of type I diabetes.

NCBI and Uniprot Product Information

• NCBI GI #: 69122931
• NCBI GeneID: 27097
• NCBI Accession #: NP_001020418.1
• NCBI GenBank Nucleotide #: NP_001020418.1
• UniProt Accession #: O75529
• Molecular Weight: ~ 66kDa
• NCBI Official Full Name: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform b
• NCBI Official Synonym Full Names: TATA-box binding protein associated factor 5 like
• NCBI Official Symbol: TAF5L
• NCBI Official Synonym Symbols: PAF65B
• NCBI Protein Information: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
• UniProt Protein Name: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
• Protein Family: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor
• UniProt Gene Name: TAF5L
• UniProt Synonym Gene Names: PAF65B; PAF65-beta
• UniProt Entry Name: TAF5L_HUMAN

NCBI Description

The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TAF5L: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Belongs to the WD repeat TAF5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: nucleoplasm; nucleus

Molecular Function: histone acetyltransferase activity; transcription coactivator activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent