Rabbit TADA2L Polyclonal Antibody | anti-TADA2L antibody

TADA2L Polyclonal Antibody

Cat. Num. AAA3006250

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunocytochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TADA2L; Polyclonal Antibody; TADA2L Polyclonal Antibody; Transcriptional adapter 2-alpha; Transcriptional adapter 2-like; ADA2-like protein; TADA2A; KL04P; anti-TADA2L antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TADA2L polyclonal antibody detects endogenous levels of TADA2L protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 443

• Applicable Applications for anti-TADA2L antibody: Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: WB: 1:500-1:1000; ICC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 248-293 of Human TADA2L.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of TADA2L polyclonal antibody at 1:500 dilutionLane1:MCF-7 cell lysateLane2:sp2/0 cell lysateLane3:H9C2 cell lysate)

Related Product Information for anti-TADA2L antibody

TADA2L (transcriptional adapter 2-like), also known as TADA2A (transcriptional adapter 2-alpha) or ADA2-like protein, is a 443 amino acid nuclear protein that exists as 2 alternatively spliced isoforms. While most abundantly expressed in testis, TADA2L is present in all tissues. TADA2L contains one SANT domain and one SWIRM domain, and interacts with GCN5 and GR (NR3C1). Its ability to bind double-stranded DNA allows TADA2L to play a role in chromatin remodeling. Although it makes up part of the PCAF complex, TADA2L is also a component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. The gene that encodes TADA2L contains 71, 408 bases and maps to human chromosome 17q12. Chromosome 7 houses over 1, 000 genes, comprises nearly 5% of the human genome and has been linked to osteogenesis imperfecta, Pendred syndrome, lissencephaly, citrullinemia and Shwachman-Diamond syndrome.

NCBI and Uniprot Product Information

• NCBI GI #: 260656022
• NCBI Accession #: NP_001159577.1
• NCBI GenBank Nucleotide #: NP_001159577.1
• UniProt Accession #: O75478
• Molecular Weight: ~ 51kDa
• NCBI Official Full Name: transcriptional adapter 2-alpha isoform a
• UniProt Protein Name: Transcriptional adapter 2-alpha
• UniProt Gene Name: TADA2A
• UniProt Synonym Gene Names: TADA2L; ADA2-like protein
• UniProt Entry Name: TAD2A_HUMAN

Uniprot Description

TADA2A: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q12-q21

Cellular Component: PCAF complex; chromosome; nucleus

Molecular Function: histone acetyltransferase activity; DNA binding; zinc ion binding; transcription cofactor activity; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent