Rabbit anti-Human TACR1 Polyclonal Antibody | anti-TACR1 antibody

TACR1, ID (TACR1, NK1R, TAC1R, Substance-P receptor, NK-1 receptor, Tachykinin receptor 1) (APC)

Cat. Num. AAA6353260

• Gene Names: TACR1; SPR; NK1R; NKIR; TAC1R
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TACR1; Polyclonal Antibody; ID (TACR1; NK1R; TAC1R; Substance-P receptor; NK-1 receptor; Tachykinin receptor 1) (APC); Tachykinin receptor 1; anti-TACR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-TACR1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TACR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-248 amino acids from the Central region of human TACR1.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TACR1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TACR1 antibody detected the TACR1 protein (arrow).)

Related Product Information for anti-TACR1 antibody

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq].

Product Categories/Family for anti-TACR1 antibody

Antibodies; Receptors

References

Saus, E., et al. J Psychiatr Res 44(14):971-978(2010). Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010): Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Davila, S., et al. Genes Immun. 11(3):232-238(2010). Herlyn, P., et al. Clin J Pain 26(3):175-181(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 4507343
• NCBI GeneID: 6869
• NCBI Accession #: NP_001049.1; NP_056542.1
• NCBI GenBank Nucleotide #: NM_001058.3
• UniProt Accession #: P25103; A8K150
• Molecular Weight: 46,251 Da
• NCBI Official Full Name: substance-P receptor isoform long
• NCBI Official Synonym Full Names: tachykinin receptor 1
• NCBI Official Symbol: TACR1
• NCBI Official Synonym Symbols: SPR; NK1R; NKIR; TAC1R
• NCBI Protein Information: substance-P receptor; NK-1R; NK-1 receptor; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
• UniProt Protein Name: Substance-P receptor
• Protein Family: Substance-P receptor
• UniProt Gene Name: TACR1
• UniProt Synonym Gene Names: NK1R; TAC1R; SPR; NK-1R
• UniProt Entry Name: NK1R_HUMAN

NCBI Description

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

Uniprot Description

TACR1: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: cell surface; integral to plasma membrane; dendrite; cytoplasm; plasma membrane

Molecular Function: protein binding; substance P receptor activity; tachykinin receptor activity

Biological Process: response to nicotine; tachykinin signaling pathway; positive regulation of leukocyte migration; response to morphine; positive regulation of saliva secretion; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; behavioral response to pain; regulation of smooth muscle cell migration; positive regulation of lymphocyte proliferation; positive regulation of stress fiber formation; positive regulation of action potential; response to electrical stimulus; inflammatory response; angiotensin mediated drinking behavior; associative learning; detection of abiotic stimulus; positive regulation of synaptic transmission, cholinergic; regulation of smooth muscle cell proliferation; eating behavior; positive regulation of hormone secretion; positive regulation of synaptic transmission, GABAergic; positive regulation of ossification; positive regulation of vascular permeability; response to ethanol; long-term memory; smooth muscle contraction involved in micturition; response to heat; response to ozone; operant conditioning; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); sperm ejaculation; response to progesterone stimulus; positive regulation of epithelial cell proliferation; positive regulation of blood pressure; acute inflammatory response