Rabbit anti-Human TAC3 Polyclonal Antibody | anti-TAC3 antibody

TAC3, ID (TAC3, NKNB, Tachykinin-3, ZNEUROK1, Neurokinin-B, Neuromedin-K) (Azide free) (HRP)

Cat. Num. AAA6353219

• Gene Names: TAC3; NKB; HH10; NKNB; PRO1155; ZNEUROK1
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TAC3; Polyclonal Antibody; ID (TAC3; NKNB; Tachykinin-3; ZNEUROK1; Neurokinin-B; Neuromedin-K) (Azide free) (HRP); Neuromedin-K; anti-TAC3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-TAC3 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:10-50; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: TAC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-83 amino acids from the Central region of human TAC3.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TAC3 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the TAC3 antibody detected the TAC3 protein (arrow).)

Immunohistochemistry (IHC)

(TAC3 Antibody (Center) (AP14366c)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TAC3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-TAC3 antibody

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants.

Product Categories/Family for anti-TAC3 antibody

Antibodies; Proteins

References

Klassert, T.E., et al. J. Neuroimmunol. 227 (1-2), 202-207 (2010): Hrabovszky, E., et al. Eur. J. Neurosci. 31(11):1984-1998(2010). Gianetti, E., et al. J. Clin. Endocrinol. Metab. 95(6):2857-2867(2010). Young, J., et al. J. Clin. Endocrinol. Metab. 95(5):2287-2295(2010). Semple, R.K., et al. Front Horm Res 39, 133-141 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 295849290
• NCBI GeneID: 6866
• NCBI Accession #: NP_001171525.1; NP_037383.1
• NCBI GenBank Nucleotide #: NM_001178054.1
• UniProt Accession #: Q9UHF0; Q6IAG2; Q71BC6; Q71BC9
• Molecular Weight: 11,358 Da
• NCBI Official Full Name: tachykinin-3 isoform 2 preproprotein
• NCBI Official Synonym Full Names: tachykinin 3
• NCBI Official Symbol: TAC3
• NCBI Official Synonym Symbols: NKB; HH10; NKNB; PRO1155; ZNEUROK1
• NCBI Protein Information: tachykinin-3; gamma tachykinin 3; neurokinin b; neuromedin K; preprotachykinin B; preprotachykinin-B
• UniProt Protein Name: Tachykinin-3
• Protein Family: Tachykinin
• UniProt Gene Name: TAC3
• UniProt Synonym Gene Names: NKNB; NKB
• UniProt Entry Name: TKNK_HUMAN

NCBI Description

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Description

TAC3: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; receptor binding

Biological Process: tachykinin signaling pathway; neuropeptide signaling pathway; female pregnancy

Disease: Hypogonadotropic Hypogonadism 10 With Or Without Anosmia