Rabbit anti-Human, Mouse TAB2 Polyclonal Antibody | anti-TAB2 antibody

Anti-TAB2 Antibody

Cat. Num. AAA8308322

• Gene Names: TAB2; CHTD2; TAB-2; MAP3K7IP2
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Immunogen Affinity Chromatography
• Synonyms: TAB2; Polyclonal Antibody; Anti-TAB2 Antibody; KIAA0733; MAP3K7IP2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2; anti-TAB2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of TAB2 protein.
• Purity/Purification: Purified by Immunogen Affinity Chromatography
• Form/Format: Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

• Applicable Applications for anti-TAB2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein of human TAB2. The exact sequence is proprietary.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of TAB2 expression in HepG2 (A), MCF7 (B), mouse liver (C) whole cell lysates.)

Related Product Information for anti-TAB2 antibody

Rabbit polyclonal antibody to TAB2

NCBI and Uniprot Product Information

• NCBI GI #: 14149669
• NCBI GeneID: 23118
• NCBI Accession #: NP_055908
• NCBI GenBank Nucleotide #: NM_015093.5
• UniProt Accession #: Q9NYJ8; Q99K90
• Molecular Weight: 58,131 Da
• NCBI Official Full Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a
• NCBI Official Synonym Full Names: TGF-beta activated kinase 1/MAP3K7 binding protein 2
• NCBI Official Symbol: TAB2
• NCBI Official Synonym Symbols: CHTD2; TAB-2; MAP3K7IP2
• NCBI Protein Information: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TAK1-binding protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2
• UniProt Protein Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
• Protein Family: TGF-beta-activated kinase 1 and MAP3K7-binding protein
• UniProt Gene Name: TAB2
• UniProt Synonym Gene Names: KIAA0733; MAP3K7IP2; TAB-2
• UniProt Entry Name: TAB2_HUMAN

NCBI Description

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Description

TAB2: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: plasma membrane; endosome membrane; cytosol

Molecular Function: protein binding; zinc ion binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; heart development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; positive regulation of protein kinase activity; toll-like receptor signaling pathway; JNK cascade; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway

Disease: Congenital Heart Defects, Multiple Types, 2