Rabbit SYT11 Polyclonal Antibody | anti-SYT11 antibody

SYT11 (Synaptotagmin-11, Synaptotagmin XI, SytXI, SYT11, KIAA0080) (HRP)

Cat. Num. AAA6459631

• Gene Names: SYT11; SYT12; sytXI
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Purified
• Synonyms: SYT11; Polyclonal Antibody; SYT11 (Synaptotagmin-11; Synaptotagmin XI; SytXI; KIAA0080) (HRP); anti-SYT11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes SYT11. Species Crossreactivity: human, mouse, rat
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-SYT11 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to SYT11.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.

Product Categories/Family for anti-SYT11 antibody

Antibodies; Syntaxin; Synaptotagmin; Synaptophysin

References

1. Nomura N., et al. DNA Res. 1:223-229(1994). 2. Ohara O., et al. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. 3. Ota T., et al. Nat. Genet. 36:40-45(2004). 4. Bechtel S., et al. BMC Genomics 8:399-399(2007). 5. Gregory S.G., et al. Nature 441:315-321(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 216548478
• NCBI GeneID: 23208
• NCBI Accession #: NP_689493.3
• NCBI GenBank Nucleotide #: NM_152280.4
• UniProt Accession #: Q9BT88; Q14998; Q5W0D4; Q68CT5; Q8IXU3; Q96SU2
• Molecular Weight: 48,297 Da
• NCBI Official Full Name: synaptotagmin-11
• NCBI Official Synonym Full Names: synaptotagmin XI
• NCBI Official Symbol: SYT11
• NCBI Official Synonym Symbols: SYT12; sytXI
• NCBI Protein Information: synaptotagmin-11; synaptotagmin 12
• UniProt Protein Name: Synaptotagmin-11
• Protein Family: Synaptotagmin
• UniProt Gene Name: SYT11
• UniProt Synonym Gene Names: KIAA0080; SytXI
• UniProt Entry Name: SYT11_HUMAN

NCBI Description

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

Uniprot Description

SYT11: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Belongs to the synaptotagmin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: synaptic vesicle; synaptic vesicle membrane; integral to plasma membrane; cell junction

Molecular Function: protein binding; calcium-dependent phospholipid binding; transporter activity; calcium ion binding

Biological Process: transport; negative regulation of neurotransmitter secretion