Western Blot (WB)
(Western Blot (WB) analysis of Synuclein-beta (S118) pAb at 1:500 dilutionLane1:The Brain tissue lysate of Mouse (20ug) Lane2:The Brain tissue lysate of Rat (40ug))
Rabbit Synuclein-beta Polyclonal Antibody | anti-S118 antibody
Synuclein-beta (S118) Polyclonal Antibody
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunofluorescence
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
Synuclein-beta; Polyclonal Antibody; Synuclein-beta (S118) Polyclonal Antibody; Beta-synuclein; SNCB; Synuclein beta; beta-Synuclein; anti-S118 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Synuclein beta (S118) polyclonal antibody detects endogenous levels of Synuclein beta protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
134
Applicable Applications for anti-S118 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
WB: 1:500-1:1000
IHC: 1:50-1:200
IF: 1:50-1:200
IHC: 1:50-1:200
IF: 1:50-1:200
Immunogen
Synthetic peptide, corresponding to amino acids 82-140 of Human Synuclein-beta.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot (WB) analysis of Synuclein-beta (S118) pAb at 1:500 dilutionLane1:The Brain tissue lysate of Mouse (20ug) Lane2:The Brain tissue lysate of Rat (40ug))
Western Blot (WB)
(Western Blot (WB) analysis of Synuclein-beta (S118) pAb at 1:500 dilutionLane1:The Brain tissue lysate of Mouse (20ug) Lane2:The Brain tissue lysate of Rat (40ug))
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analyzes of Synuclein-beta (S118) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.)
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analyzes of Synuclein-beta (S118) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.)
Related Product Information for anti-S118 antibody
The synuclein family members, including alpha-synuclein (also designated NACP for non-beta amyloid component) and beta-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. alpha-synuclein is localized to neuronal cell bodies and synapses. alpha-synuclein was first identified as a component of Alzheimer's disease amyloid plaques. Abnormal platelet function in Alzheimer's disease has been demonstrated. During megakaryocytic differentiation alpha-synuclein was found to be upregulated, while beta-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of alpha-synuclein has been found in patients with early onset Parkinson's disease.
NCBI and Uniprot Product Information
NCBI GI #
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 14kDa
NCBI Official Full Name
beta-synuclein isoform 1
UniProt Protein Name
Beta-synuclein
UniProt Gene Name
SNCB
UniProt Entry Name
SYUB_HUMAN
Uniprot Description
SNCB: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May play a role in neuronal plasticity, is abundant in neurofibrillary lesions of Alzheimer's patients. Highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: nucleoplasm; Golgi apparatus; growth cone; mitochondrion; cell soma; cytoplasm; terminal button; inclusion body
Molecular Function: phospholipase inhibitor activity; beta-tubulin binding; calcium ion binding; alpha-tubulin binding
Biological Process: synaptic transmission; negative regulation of catalytic activity; synapse organization and biogenesis; negative regulation of neuron apoptosis; dopamine metabolic process
Disease: Dementia, Lewy Body
Similar Products
Product Notes
The S118 sncb (Catalog #AAA3000905) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Synuclein-beta (S118) Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Synuclein-beta can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:500-1:1000 IHC: 1:50-1:200 IF: 1:50-1:200. Researchers should empirically determine the suitability of the S118 sncb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Synuclein-beta, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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