SYNCRIP antibody pair

SYNCRIP Antibody Pair

Cat. Num. AAA7041822

• Gene Names: SYNCRIP; PP68; NSAP1; GRYRBP; HNRNPQ; HNRPQ1; GRY-RBP; hnRNP-Q
• Reactivity: Guinea Pig, Bovine, Pig, Dog, Rabbit, Goat, Sheep
• Applications: ELISA
• Synonyms: SYNCRIP; Polyclonal Antibody Pair; SYNCRIP Antibody Pair; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding; cytoplasmic RNA-interacting protein; HNRPQ; NSAP1; SYNCRIP antibody pair

• Host: Capture: Rabbit; Detection: Rabbit
• Reactivity: Guinea Pig, Bovine, Pig, Dog, Rabbit, Goat, Sheep
• Clonality: Polyclonal
• Isotype: Capture: IgG; Detection: IgG
• Form/Format: Liquid
• Concentration: The concentrations and volumes of the antibodies may vary and be lot specific. Details will be on the vial labels. (varies by lot)
• Sequence Length: 453

• Applicable Applications for SYNCRIP antibody pair: Sandwich ELISA (EIA)
• Application Notes: We recommend using the capture antibody at a concentration of 2ug/ml and the detection antibody at a concentration of 0.67ug/ml.
• Immunogen Species: Human
• Conjugation: Capture: Non-conjugated; Detection: Biotin conjugated
• Recommended Standard: HeLa cell; HL-60 cell; (Standards are recommendations only. Compatibility of the standards in the user developed application needs to be established and confirmed by the researcher.
• Storage Buffer: Capture: 50% Glycerol, 0.01M PBS, PH 7.4; Detection: 50% Glycerol, 0.01M PBS, PH 7.4
• Other Note: Immunogen information is company proprietary information. Antibodies are sold as a pair and not available separately.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze/thaw cycles. When stored properly, products should be stable for at least 5 months.

NCBI and Uniprot Product Information

• NCBI GI #: 116283697
• NCBI GeneID: 10492
• Molecular Weight: 46,328 Da
• NCBI Official Full Name: SYNCRIP protein, partial
• NCBI Official Synonym Full Names: synaptotagmin binding cytoplasmic RNA interacting protein
• NCBI Official Symbol: SYNCRIP
• NCBI Official Synonym Symbols: PP68; NSAP1; GRYRBP; HNRNPQ; HNRPQ1; GRY-RBP; hnRNP-Q
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein Q
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein Q
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: SYNCRIP
• UniProt Synonym Gene Names: HNRPQ; NSAP1; hnRNP Q; GRY-RBP
• UniProt Entry Name: HNRPQ_HUMAN

NCBI Description

This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]

Uniprot Description

NSAP1: a heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. A component of the spliceosome. Five alternatively spliced isoforms have been described. Isoform 1, 2 and 3 are associated with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to ACF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.

Protein type: Spliceosome; RNA splicing; RNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q14-q15

Cellular Component: cell soma; endoplasmic reticulum; membrane; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: mRNA 3'-UTR binding; mRNA 5'-UTR binding; nucleotide binding; poly(A) binding; protein binding; RNA binding

Biological Process: circadian rhythm; negative regulation of translation; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; positive regulation of translation; RNA processing; RNA splicing; viral reproduction