Western Blot (WB)
(Anti-SynCAM antibody, MBS177063, All Western blottingAll lanes: Anti-CADM1(MBS177063) at 0.5ug/mlLane 1: A549 Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugLane 3: RAJI Whole Cell Lysate at 40ugLane 4: HELA Whole Cell Lysate at 40ugPredicted bind size: 60KDObserved bind size: 60KD )
Rabbit SynCAM Polyclonal Antibody | anti-CADM1 antibody
Anti-SynCAM antibody
Western Blot (WB)
(Anti-SynCAM antibody, MBS177063, All Western blottingAll lanes: Anti-CADM1(MBS177063) at 0.5ug/mlLane 1: A549 Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugLane 3: RAJI Whole Cell Lysate at 40ugLane 4: HELA Whole Cell Lysate at 40ugPredicted bind size: 60KDObserved bind size: 60KD )
Western Blot (WB)
(Anti-SynCAM antibody, MBS177063, All Western blottingAll lanes: Anti-CADM1(MBS177063) at 0.5ug/mlLane 1: A549 Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugLane 3: RAJI Whole Cell Lysate at 40ugLane 4: HELA Whole Cell Lysate at 40ugPredicted bind size: 60KDObserved bind size: 60KD )
Background: Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene. This gene is also known as IGSF4, SYNCAM or TSLC1, and it is mapped to 11q23.3. CADM1 functions as a homophilic cell adhesion molecule at the synapse. Expression of the isolated cytoplasmic tail of CADM1 in neurons inhibited synapse assembly. Conversely, expression of full-length CADM1 in nonneuronal cells induced synapse formation by cocultured hippocampal neurons with normal release properties. CADM1 has been shown to interact with EPB41L3.
NCBI and Uniprot Product Information
Uniprot Description
CADM1: a single-pass type I membrane protein that ediates homophilic cell-cell adhesion, and heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Tumor suppressor; Vesicle; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 11q23.2
Cellular Component: synaptic vesicle; axon; basolateral plasma membrane; dendrite; integral to membrane; plasma membrane; intercellular junction
Molecular Function: protein binding; protein homodimerization activity; cell adhesion molecule binding; PDZ domain binding; receptor binding
Biological Process: intercellular junction assembly and maintenance; unidimensional cell growth; apoptosis; activated T cell proliferation; cell recognition; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity; liver development; calcium-independent cell-cell adhesion; heterophilic cell adhesion; synaptogenesis; detection of stimulus; spermatogenesis; brain development; homophilic cell adhesion; cell differentiation; T cell mediated cytotoxicity; positive regulation of cytokine secretion
Research Articles on CADM1
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Product Notes
The CADM1 cadm1 (Catalog #AAA177063) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SynCAM antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SynCAM can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CADM1 cadm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SynCAM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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