Rabbit anti-Virus Swine H1N1 Hemagglutinin Polyclonal Antibody | anti-HA antibody

Swine H1N1 Hemagglutinin Antibody

Cat. Num. AAA9409069

• Reactivity: Virus
• Applications: ELISA
• Purity: Affinity chromatography purified via peptide column
• Synonyms: Swine H1N1 Hemagglutinin; Polyclonal Antibody; Swine H1N1 Hemagglutinin Antibody; Swine-Origin Influenza A (H1N1) Hemagglutinin Antibody; Swine-Origin Influenza A (H1N1) Hemagglutinin; S-OIV A Hemagglutinin; Swine flu H1; HA; anti-HA antibody

• Host: Rabbit
• Reactivity: Virus
• Clonality: Polyclonal
• Specificity: This antibody is specific for the novel swine influenza Hemagglutinin and will not recognize the corresponding Hemagglutinin sequence from the seasonal H1N1 influenza (A/Brisbane/59/2007 (H1N1)). Will not cross-react with peptide corresponding to the seasonal H1N1 Hemagglutinin.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 566

• Applicable Applications for anti-HA antibody: ELISA (EIA)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a synthetic peptide from the novel swine influenza Hemagglutinin protein.The peptide sequence is unique from the peptide sequence for product 5237 and 5233.This antibody is a cognate pair with product number 5239.
• Target Name: Swine H1N1 Hemagglutinin
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA)

(ELISA results using Swine H1N1 Hemagglutinin antibody at 1 ug/mL and the blocking and corresponding peptides at 50, 10, 2 and 0 ng/ml.)

ELISA (EIA)

(ELISA results using Swine H1N1 Hemagglutinin antibody at 1 ug/mL and the blocking and corresponding peptides at 50, 10, 2 and 0 ng/ml.)

Related Product Information for anti-HA antibody

Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States. The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic. Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible Neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin. The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups.

Product Categories/Family for anti-HA antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 229535834
• Molecular Weight: 63,236 Da
• NCBI Official Full Name: hemagglutinin
• UniProt Protein Name: Hemagglutinin
• Protein Family: Protein
• UniProt Gene Name: HA
• UniProt Entry Name: C4AL34_9INFA

Uniprot Description

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.