Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human placenta using MBS1495812 at dilution 1:100)
Rabbit anti-Human Suppressor of tumorigenicity 14 protein Polyclonal Antibody | anti-ST14 antibody
Rabbit anti-human Suppressor of tumorigenicity 14 protein polyclonal Antibody(ST14)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human placenta using MBS1495812 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human placenta using MBS1495812 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
Uniprot Description
ST14: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH). ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair. Belongs to the peptidase S1 family.
Protein type: Membrane protein, integral; Protease; EC 3.4.21.109
Chromosomal Location of Human Ortholog: 11q24-q25
Cellular Component: basolateral plasma membrane; extracellular space; extrinsic to plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: serine-type endopeptidase activity; serine-type peptidase activity
Biological Process: keratinocyte differentiation; neural tube closure; proteolysis
Disease: Ichthyosis, Congenital, Autosomal Recessive 11
Research Articles on ST14
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Product Notes
The ST14 st14 (Catalog #AAA1495812) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Suppressor of tumorigenicity 14 protein polyclonal Antibody(ST14) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Suppressor of tumorigenicity 14 protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC:1:20-1:200. Researchers should empirically determine the suitability of the ST14 st14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Suppressor of tumorigenicity 14 protein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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