Western Blot (WB)
(STX16 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the STX16 antibody detected the STX16 protein (arrow).)
Rabbit STX16 Polyclonal Antibody | anti-STX16 antibody
STX16 Antibody (C-term)
Western Blot (WB)
(STX16 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the STX16 antibody detected the STX16 protein (arrow).)
Western Blot (WB)
(STX16 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the STX16 antibody detected the STX16 protein (arrow).)
Flow Cytometry (FC/FACS)
(STX16 Antibody (C-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(STX16 Antibody (C-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
syntaxin or t-SNARE (target-SNAP receptor) family. These proteins
are found on cell membranes and serve as the targets for V-SNARES
(vesicle-SNAP receptors) permitting specific synaptic vesicle
docking and fusion. A microdeletion in the region of chromosome 20
where this gene is located has been associated with
pseudohypoparathyroidism type Ib. Multiple transcript variants
encoding different isoforms have been found for this gene.
Ganley, I.G., et al. J. Cell Biol. 180(1):159-172(2008)
Chua, C.E., et al. Mol. Membr. Biol. 25(1):35-45(2008)
Amessou, M., et al. J. Cell. Sci. 120 (PT 8), 1457-1468 (2007) :
Linglart, A., et al. Am. J. Hum. Genet. 76(5):804-814(2005)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]
Uniprot Description
STX16: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B). Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B. Belongs to the syntaxin family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 20q13.32
Cellular Component: Golgi apparatus; Golgi cisterna; focal adhesion; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane; endomembrane system; trans-Golgi network; cytosol; Golgi membrane; SNARE complex; membrane; perinuclear region of cytoplasm; cytoplasm; nucleolus
Molecular Function: SNAP receptor activity; SNARE binding; protein binding; syntaxin binding
Biological Process: vesicle fusion; intra-Golgi vesicle-mediated transport; intracellular protein transport; vesicle docking; retrograde transport, endosome to Golgi
Disease: Pseudohypoparathyroidism, Type Ib
Research Articles on STX16
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Product Notes
The STX16 stx16 (Catalog #AAA9206631) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 247-274. The STX16 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's STX16 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the STX16 stx16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "STX16, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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