Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/30.)
Rabbit anti-Human STRA6 Polyclonal Antibody | anti-STRA6 antibody
STRA6 Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/30.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/30.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Description
STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: protein complex; plasma membrane; integral to membrane
Molecular Function: receptor activity; vitamin transporter activity
Biological Process: developmental growth; blood vessel development; phototransduction, visible light; adrenal gland development; neuromuscular process; heart development; ear development; positive regulation of JAK-STAT cascade; digestive tract morphogenesis; learning; vocal learning; female genitalia development; nose morphogenesis; smooth muscle development; positive regulation of behavior; retinoic acid metabolic process; artery morphogenesis; feeding behavior; retinoid metabolic process; kidney development; cognition; embryonic gut development; alveolus development; lung development
Disease: Microphthalmia, Syndromic 9
Research Articles on STRA6
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Product Notes
The STRA6 stra6 (Catalog #AAA9414877) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The STRA6 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's STRA6 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:25-1:100. Researchers should empirically determine the suitability of the STRA6 stra6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "STRA6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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