Rabbit Stonin-1 Polyclonal Antibody | anti-W718 antibody

Stonin-1 (W718) Polyclonal Antibody

Cat. Num. AAA3002711

• Gene Names: STON1; SALF; SBLF; STN1; STNB1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Stonin-1; Polyclonal Antibody; Stonin-1 (W718) Polyclonal Antibody; Stonin 1; Stonin1; Stoned B-like factor; STON1; SALF; SBLF; STN1; anti-W718 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Stonin-1 (W718) polyclonal antibody detects endogenous levels of Stonin-1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1158

• Applicable Applications for anti-W718 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 680-740 of Human Stonin-1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Testing Data

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of Stonin-1 (W718) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.)

Related Product Information for anti-W718 antibody

Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 310703592
• NCBI GeneID: 11037
• NCBI Accession #: NP_001185522.1
• NCBI GenBank Nucleotide #: NP_001185522.1
• UniProt Accession #: Q9Y6Q2
• Molecular Weight: ~ 83kDa
• NCBI Official Full Name: STON1-GTF2A1L protein isoform 2
• NCBI Official Synonym Full Names: stonin 1
• NCBI Official Symbol: STON1
• NCBI Official Synonym Symbols: SALF; SBLF; STN1; STNB1
• NCBI Protein Information: stonin-1
• UniProt Protein Name: Stonin-1
• Protein Family: Stonin
• UniProt Gene Name: STON1
• UniProt Synonym Gene Names: SALF; SBLF; STN1
• UniProt Entry Name: STON1_HUMAN

NCBI Description

Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

Uniprot Description

STON1: May be involved in the endocytic machinery. Belongs to the Stoned B family.

Chromosomal Location of Human Ortholog: 2p16.3

Cellular Component: clathrin adaptor complex

Biological Process: intracellular protein transport; regulation of endocytosis; endocytosis