Rabbit anti-Human STMN2 Polyclonal Antibody | anti-STMN2 antibody

STMN2, CT (STMN2, SCG10, SCGN10, Stathmin-2, Superior cervical ganglion-10 protein) (Biotin)

Cat. Num. AAA6352128

• Gene Names: STMN2; SCG10; SCGN10
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: STMN2; Polyclonal Antibody; CT (STMN2; SCG10; SCGN10; Stathmin-2; Superior cervical ganglion-10 protein) (Biotin); Superior cervical ganglion-10 protein; anti-STMN2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-STMN2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: STMN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the C-terminal region of human STMN2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(STMN2 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the STMN2 antibody detected the STMN2 protein (arrow).)

Related Product Information for anti-STMN2 antibody

This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6.

Product Categories/Family for anti-STMN2 antibody

Antibodies; Cancer Markers

References

Paradis, V., et al. Am. J. Pathol. 177(4):1791-1797(2010). Rowe, D.D., et al. Brain Res. (2010). In press: Alves, M.M., et al. Hum. Mol. Genet. 19(18):3642-3651(2010). Xu, H., et al. J. Biol. Chem. 285(6):3548-3553(2010). Mead, S., et al. Lancet Neurol 8(1):57-66(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 34850061
• NCBI GeneID: 11075
• NCBI Accession #: NP_008960.2
• NCBI GenBank Nucleotide #: NM_007029.3
• UniProt Accession #: Q93045; O14952; Q6PK68; A8K9M2; G3V110
• Molecular Weight: 21,802 Da
• NCBI Official Full Name: stathmin-2 isoform 2
• NCBI Official Synonym Full Names: stathmin 2
• NCBI Official Symbol: STMN2
• NCBI Official Synonym Symbols: SCG10; SCGN10
• NCBI Protein Information: stathmin-2; stathmin-like 2; superior cervical ganglion-10 protein; neuron-specific growth-associated protein; superior cervical ganglia, neural specific 10; neuronal growth-associated protein (silencer element)
• UniProt Protein Name: Stathmin-2
• Protein Family: Stathmin
• UniProt Gene Name: STMN2
• UniProt Synonym Gene Names: SCG10; SCGN10; Protein SCG10
• UniProt Entry Name: STMN2_HUMAN

NCBI Description

This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

Uniprot Description

STMN2: a cytoskeletal protein that may play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth. Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Neuron specific.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: Golgi apparatus; neuron projection; growth cone; cell soma; membrane; perinuclear region of cytoplasm; axon; lamellipodium; cytoplasm; vesicle; endosome

Molecular Function: tubulin binding; protein binding; calcium-dependent protein binding

Biological Process: positive regulation of microtubule depolymerization; negative regulation of microtubule depolymerization; negative regulation of microtubule polymerization