Rabbit anti-Human STK17B Polyclonal Antibody | anti-STK17B antibody

STK17B, CT (STK17B, DRAK2, Serine/threonine-protein kinase 17B, DAP kinase-related apoptosis-inducing protein kinase 2) (Biotin)

Cat. Num. AAA6352007

• Gene Names: STK17B; DRAK2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: STK17B; Polyclonal Antibody; CT (STK17B; DRAK2; Serine/threonine-protein kinase 17B; DAP kinase-related apoptosis-inducing protein kinase 2) (Biotin); DAP kinase-related apoptosis-inducing protein kinase 2; anti-STK17B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-STK17B antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: STK17B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-348 amino acids from the C-terminal region of human STK17B.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(STK17B Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the STK17B antibody detected the STK17B protein (arrow).)

Product Categories/Family for anti-STK17B antibody

Antibodies; Protein Kinases

References

Rose, J. Phd, et al. Mol. Med. (2010). In press: Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009): Doherty, G.A., et al. Br. J. Cancer 101(3):483-491(2009). Gatzka, M., et al. J. Immunol. 183(1):285-297(2009). Friedrich, M.L., et al. J. Biol. Chem. 282(7):4573-4584(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 4758194
• NCBI GeneID: 9262
• NCBI Accession #: NP_004217.1
• NCBI GenBank Nucleotide #: NM_004226.3
• UniProt Accession #: O94768
• Molecular Weight: 42,344 Da
• NCBI Official Full Name: serine/threonine-protein kinase 17B
• NCBI Official Synonym Full Names: serine/threonine kinase 17b
• NCBI Official Symbol: STK17B
• NCBI Official Synonym Symbols: DRAK2
• NCBI Protein Information: serine/threonine-protein kinase 17B; death-associated protein kinase-related 2; DAP kinase-related apoptosis-inducing protein kinase 2
• UniProt Protein Name: Serine/threonine-protein kinase 17B
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: STK17B
• UniProt Synonym Gene Names: DRAK2
• UniProt Entry Name: ST17B_HUMAN

Uniprot Description

DRAK2: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.

Protein type: Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; CAMK group; DAPK family

Chromosomal Location of Human Ortholog: 2q32.3

Cellular Component: plasma membrane; ER-Golgi intermediate compartment; nucleus; actin cytoskeleton

Molecular Function: protein serine/threonine kinase activity; ATP binding; protein kinase activity

Biological Process: apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation