Mouse anti-Human STK11IP Polyclonal Antibody | anti-STK11IP antibody

STK11IP (Serine/Threonine-protein Kinase 11-interacting Protein, LKB1-interacting Protein 1, KIAA1898, LIP1, LKB1IP, STK11IP1)

Cat. Num. AAA646516

• Gene Names: STK11IP; LIP1; LKB1IP; STK11IP1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: STK11IP; Polyclonal Antibody; STK11IP (Serine/Threonine-protein Kinase 11-interacting Protein; LKB1-interacting Protein 1; KIAA1898; LIP1; LKB1IP; STK11IP1); Anti -STK11IP (Serine/Threonine-protein Kinase 11-interacting Protein; anti-STK11IP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human STK11IP.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MFGSAPQRPVAMTTAQRDSLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWPVGSTPETSGGPDLSDSLSSGGVVTQPLLHKVKSRVHVRRASISEPSDTDPEPGTLNPSPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGIRGRECFLRVTSAHLFEVELQAARTLERLELQSLEAAEIEPEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLTPVTNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCPNCGSDHVVLLAVSRGTPNRERKQGEQSLAPSPFASPVCHPPGHGDHLDRAKNSPPQAPSTRDHGSWSLSPPPERCGLRSVDHRLRLFLDVEVFSDAQEEFQCCLKVPVALAGHTGEFMCLVVVSDRRLYLLKVTGEMREPPASWLQLTLAVPLQDLSGIELGLAGQSLRLEWAAGAGRCVLLPRDARHCRAFLEELLDVLQSLPPAWRNCVSATEEEVTPQHRLWPLLEKDSSLEARQFFYLRAFLVEGPSTCLVSLLLTPSTLFLLDEDAAGSPAEPSPPAASGEASEKVPPSGPGPAVRVREQQPLSSLSSVLLYRSAPEDLRLLFYDEVSRLESFWALRVVCQEQLTALLAWIREPWEELFSVGLRTVIQEALALDR

• Applicable Applications for anti-STK11IP antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human STK11IP, aa1-1099 (AAH34051.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of STK11IP expression in transfected 293T cell line by STK11IP polyclonal antibody. Lane 1: STK11IP transfected lysate (120.89kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-STK11IP antibody

LKB1 (also STK11 and JBS) is a 55kD member of the CAMK Ser/Thr protein kinase family. It is ubiquitously expressed, and considered to be a tumor suppressor. LKB1 is both nuclear and cytoplasmic, and appears to contribute to cell polarization, G1 cell cycle arrest and Wnt signaling. It is known to complex with STRAD and CAB39/MO25, and phosphorylate PTEN plus p53. Human LKB1 is 433aa in length. It contains a protein kinase domain (aa49-309) and a prenylation motif (CysLysGlnGln) over aa430-433. There are two potential isoforms of LKB1. One shows a nine aa insertion after Tyr126, while another shows a 34aa substitution for aa371-433. Over aa242-433, human and mouse LKB1 are identical in aa sequence.

Product Categories/Family for anti-STK11IP antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 116235474
• NCBI GeneID: 114790
• NCBI Accession #: NP_443134.2
• NCBI GenBank Nucleotide #: NM_052902.2
• UniProt Accession #: Q8N1F8; Q8NAW9; Q8WXE4; Q96CN3; Q96PY9
• Molecular Weight: 121,401 Da
• NCBI Official Full Name: serine/threonine-protein kinase 11-interacting protein
• NCBI Official Synonym Full Names: serine/threonine kinase 11 interacting protein
• NCBI Official Symbol: STK11IP
• NCBI Official Synonym Symbols: LIP1; LKB1IP; STK11IP1
• NCBI Protein Information: serine/threonine-protein kinase 11-interacting protein; LKB1 interacting protein; STK11 interacting protein; LKB1-interacting protein 1; serine/threonine kinase 11-interacting protein
• UniProt Protein Name: Serine/threonine-protein kinase 11-interacting protein
• Protein Family: Serine/threonine-protein kinase 11-interacting protein
• UniProt Gene Name: STK11IP
• UniProt Synonym Gene Names: KIAA1898; LIP1; LKB1IP; STK11IP1
• UniProt Entry Name: S11IP_HUMAN

Uniprot Description

Function: May regulate STK11/LKB1 function by controlling its subcellular localization. Ref.1

Subunit structure: Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4. Interacts with STK11/LKB1 and SMAD4. Ref.1

Subcellular location: Cytoplasm. Note: Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures. Ref.1

Miscellaneous: This gene contains a polymorphic substitution resulting in a variant amino acid from Met-1 to Arg-1 compared to the official human genome. However, this variant sequence is in agreement with EST and mRNA sequences.

Sequence similarities: Belongs to the STK11IP family.Contains 8 LRR (leucine-rich) repeats.

Caution: It is uncertain whether Met-1 or Met-12 is the initiator.