Rabbit anti-Human, Mouse STING Polyclonal Antibody | anti-STING antibody

STING Rabbit pAb

Cat. Num. AAA4751498

• Gene Names: TMEM173; ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; STING-beta
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Immunogen Affinity Purified
• Synonyms: STING; Polyclonal Antibody; STING Rabbit pAb; anti-STING antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: STING Rabbit pAb recognizes endogenous levels of total STING protein.
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: In PBS (pH 7.4) containing with 0.02% Sodium Azide and 50% Glycerol.
• Sequence Length: 379

• Applicable Applications for anti-STING antibody: Western Blot (WB)
• Application Notes: WB: 1:1000
• Immunogen: Purified recombinant mouse STING protein fragments expressed in E Coli
• Subcellular Location: Endoplasmic Reticulum Membrane. Mitochondrion Outer Membrane. Cell Membrane. Cytoplasm > Perinuclear Region. In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited.
• Preparation and Storage: Store at 4 degree C short term. Store at -20 degree C long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western blot analysis of extracts from 3T3 cells using STING Rabbit pAb at 1:1000 dilution. Predicted band size: 42kDa. Observed band size: 39kDa.)

Related Product Information for anti-STING antibody

Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 38093659
• NCBI GeneID: 340061
• NCBI Accession #: NP_938023.1
• NCBI GenBank Nucleotide #: NM_198282.4
• UniProt Accession #: Q86WV6; Q3TBT3
• Molecular Weight: 42 kDa
• NCBI Official Full Name: stimulator of interferon genes protein isoform 1
• NCBI Official Synonym Full Names: transmembrane protein 173
• NCBI Official Symbol: TMEM173
• NCBI Official Synonym Symbols: ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; STING-beta
• NCBI Protein Information: stimulator of interferon genes protein
• UniProt Protein Name: Stimulator of interferon genes protein
• UniProt Gene Name: TMEM173
• UniProt Synonym Gene Names: ERIS; MITA; STING; hSTING; ERIS; hMITA
• UniProt Entry Name: STING_HUMAN

NCBI Description

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]