Rabbit anti-Human STIM2 Polyclonal Antibody | anti-STIM2 antibody

STIM2, CT (Stromal Interaction Molecule 2, FLJ39527, KIAA1482)

Cat. Num. AAA647625

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified; Purified
• Synonyms: STIM2; Polyclonal Antibody; CT (Stromal Interaction Molecule 2; FLJ39527; KIAA1482); Anti -STIM2; anti-STIM2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human STIM2. Species sequence homology: Mouse and rat.
• Purity/Purification: Purified; Purified
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-STIM2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot: 0.5-1ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to human STIM2 at C-terminal (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with STIM2 antibody at 5ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-STIM2 antibody

This gene is a member of the stromal interaction molecule (STIM) family and likely arose, with related family member STIM1, from a common ancestral gene. It encodes a type 1 transmembrane protein whose function is currently unknown, but is a likely adhesion molecule with a role in early hematopoiesis. Alternative translation initiation from an AUG and a non-AUG (UUG) start site results in the production of two different isoforms.

Product Categories/Family for anti-STIM2 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 281182842
• NCBI GeneID: 57620
• NCBI Accession #: NP_001162589.1
• NCBI GenBank Nucleotide #: NM_001169118.1
• UniProt Accession #: Q9P246; Q96BF1; Q9BQH2; Q9H8R1
• Molecular Weight: 83,971 Da
• NCBI Official Full Name: stromal interaction molecule 2 isoform 1
• NCBI Official Synonym Full Names: stromal interaction molecule 2
• NCBI Official Symbol: STIM2
• NCBI Protein Information: stromal interaction molecule 2
• UniProt Protein Name: Stromal interaction molecule 2
• Protein Family: Stromal interaction molecule
• UniProt Gene Name: STIM2
• UniProt Synonym Gene Names: KIAA1482
• UniProt Entry Name: STIM2_HUMAN

NCBI Description

This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]

Uniprot Description

Function: Plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores. Functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations. Upon mild variations of the endoplasmic reticulum Ca2+ concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca2+ release-activated Ca2+ (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca2+ influx. Ref.6 Ref.7 Ref.8 Ref.10 Ref.14 Ref.15

Subunit structure: Oligomer with STIM1. Interacts with ORAI1. Ref.1 Ref.10 Ref.12

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note: Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca2+ concentration. Ref.7 Ref.8 Ref.10

Tissue specificity: Expressed in all tissues and tumor cell lines examined. Ref.1

Post-translational modification: Glycosylated. Ref.1Phosphorylated predominantly on Ser residues. Ref.1

Sequence similarities: Contains 1 EF-hand domain.Contains 1 SAM (sterile alpha motif) domain.

Sequence caution: The sequence BAA96006.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.The sequence BAB14545.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAB14545.1 differs from that shown. Reason: Probable cloning artifact.The sequence CAB66512.2 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.