Rabbit STAT5b Polyclonal Antibody | anti-STAT5B antibody

Anti-STAT5b antibody

Cat. Num. AAA176379

• Gene Names: STAT5B; STAT5
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen affinity purified.
• Synonyms: STAT5b; Polyclonal Antibody; Anti-STAT5b antibody; Signal transducer and activator of transcription 5B; signal transducer and activator of transcription 5B; Signal transducer and activator of transcription 5B antibody; STA5B_HUMAN antibody; STAT5 antibody; Stat5b antibody; Transcription factor STAT5B antibody; anti-STAT5B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 787

• Applicable Applications for anti-STAT5B antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human STAT5b (767-787aa RRVEELLGRPMDSQWIPHAQS), identical to the related rat and mouse sequences.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-STAT5b antibody, MBS176379, Western blottingLane 1: Rat Intestine Tissue LysateLane 2: Rat Kidney Tissue LysateLane 3: HELA Cell LysateLane 4: A549 Cell LysateLane 5: MM231 Cell LysateLane 6: COLO320 Cell Lysate )

Immunohistochemistry (IHC)

(Anti-STAT5b antibody, MBS176379, IHC(P)IHC(P): Human Mammary Cancer Tissue )

Related Product Information for anti-STAT5B antibody

Description: Rabbit IgG polyclonal antibody for Signal transducer and activator of transcription 5B(STAT5B) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: STAT5B(Signal transducer and activator of transcription 5B) is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs have been identified in most placentals for which complete genome data are available. By FISH, Lin et al.(1996) mapped STAT5B to 17q11.2. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha(RARA) gene in a small subset of acute promyelocytic leukemias(APML). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML.

NCBI and Uniprot Product Information

• NCBI GI #: 41019536
• NCBI GeneID: 6777
• UniProt Accession #: P51692; Q8WWS8
• Molecular Weight: 89,866 Da
• NCBI Official Full Name: Signal transducer and activator of transcription 5B
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 5B
• NCBI Official Symbol: STAT5B
• NCBI Official Synonym Symbols: STAT5
• NCBI Protein Information: signal transducer and activator of transcription 5B; transcription factor STAT5B
• UniProt Protein Name: Signal transducer and activator of transcription 5B
• Protein Family: Signal transducer and activator of transcription
• UniProt Gene Name: STAT5B
• UniProt Entry Name: STA5B_HUMAN

NCBI Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

Uniprot Description

STAT5B: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.

Protein type: DNA-binding; Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein dimerization activity; protein binding; signal transducer activity; double-stranded DNA binding; chromatin binding; transcription factor activity; protein phosphatase binding; glucocorticoid receptor binding

Biological Process: lactation; transcription from RNA polymerase II promoter; succinate metabolic process; oxaloacetate metabolic process; positive regulation of interleukin-2 biosynthetic process; positive regulation of smooth muscle cell proliferation; T cell differentiation in the thymus; response to lipopolysaccharide; female pregnancy; positive regulation of multicellular organism growth; progesterone metabolic process; positive regulation of mitotic cell cycle; fatty acid metabolic process; positive regulation of activated T cell proliferation; response to estradiol stimulus; 2-oxoglutarate metabolic process; positive regulation of natural killer cell differentiation; sequestering of lipid; allantoin metabolic process; natural killer cell differentiation; luteinization; regulation of steroid metabolic process; development of secondary male sexual characteristics; acute-phase response; creatinine metabolic process; T cell homeostasis; positive regulation of gamma-delta T cell differentiation; Peyer's patch development; isoleucine metabolic process; negative regulation of erythrocyte differentiation; positive regulation of natural killer cell proliferation; valine metabolic process; citrate metabolic process; regulation of multicellular organism growth; development of secondary female sexual characteristics; positive regulation of cell motility; JAK-STAT cascade; liver development; positive regulation of natural killer cell mediated cytotoxicity; creatine metabolic process; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; response to ethanol; regulation of epithelial cell differentiation; response to hypoxia; positive regulation of B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; positive regulation of inflammatory response; negative regulation of apoptosis

Disease: Growth Hormone Insensitivity With Immunodeficiency