Rabbit STAR Polyclonal Antibody | anti-STAR antibody

STAR Antibody

Cat. Num. AAA2524327

• Gene Names: STAR; STARD1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: STAR; Polyclonal Antibody; STAR Antibody; STARD1; anti-STAR antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 285

• Applicable Applications for anti-STAR antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Recombinant protein of human STAR
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23523 / sc-23524 / sc-25806
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using AKT antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human esophageal cancer using STAR antibody at dilution of 1:100 (200x lens).)

Related Product Information for anti-STAR antibody

Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane (1). The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone (2, 3). StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue (3). Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis (4). The mechanism of cholesterol binding to StAR has yet to be elucidated (4).

NCBI and Uniprot Product Information

• NCBI GI #: 49456655
• NCBI GeneID: 6770
• UniProt Accession #: Q6IBK0; P49675
• Molecular Weight: 31,914 Da
• NCBI Official Full Name: STAR, partial
• NCBI Official Synonym Full Names: steroidogenic acute regulatory protein
• NCBI Official Symbol: STAR
• NCBI Official Synonym Symbols: STARD1
• NCBI Protein Information: steroidogenic acute regulatory protein, mitochondrial; START domain containing 1; START domain-containing protein 1; StAR-related lipid transfer (START) domain containing 1; cholesterol trafficker; mitochondrial steroid acute regulatory protein
• UniProt Protein Name: STAR protein
• Protein Family: Starch synthase
• UniProt Gene Name: STAR
• UniProt Entry Name: Q6IBK0_HUMAN

NCBI Description

The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]

Uniprot Description

STAR: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. May interact with TSPO. Expressed in gonads, adrenal cortex and kidney.

Protein type: Mitochondrial; Carrier; Lipid-binding

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: mitochondrial crista; neuron projection; cell soma; mitochondrial intermembrane space; cytosol

Molecular Function: cholesterol transporter activity; cholesterol binding

Biological Process: steroid metabolic process; response to nicotine; diterpenoid metabolic process; dibenzo-p-dioxin metabolic process; regulation of steroid biosynthetic process; estrogen biosynthetic process; biphenyl metabolic process; circadian sleep/wake cycle, REM sleep; negative regulation of neuron apoptosis; response to nutrient; response to corticosterone stimulus; response to drug; bile acid biosynthetic process; cholesterol metabolic process; insecticide metabolic process; positive regulation of neurogenesis; progesterone biosynthetic process; fractalkine metabolic process; phthalate metabolic process; male gonad development; intracellular cholesterol transport; response to herbicide; glucocorticoid metabolic process; response to ethanol; cellular response to insulin stimulus; response to hydrogen peroxide; response to estrogen stimulus; response to lead ion; C21-steroid hormone biosynthetic process; response to activity; response to ionizing radiation; brain development; steroid biosynthetic process; phenol metabolic process; regulation of neuronal synaptic plasticity

Disease: Lipoid Congenital Adrenal Hyperplasia