Rabbit SSTR2 Polyclonal Antibody | anti-SSTR2 antibody

SSTR2 Polyclonal Antibody

Cat. Num. AAA3006806

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: SSTR2; Polyclonal Antibody; SSTR2 Polyclonal Antibody; Somatostatin receptor type 2; SS-2-R; SS2-R; SS2R; SRIF-1; SRIF 1; SRIF1; anti-SSTR2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SSTR2 polyclonal antibody detects endogenous levels of SSTR2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 369

• Applicable Applications for anti-SSTR2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human SSTR2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of SSTR2 polyclonal antibody at 1:500 dilutionLane1:THP-1 whole cell lysateLane2:NIH-3T3 whole cell lysateLane3:H9C2 whole cell lysate)

Related Product Information for anti-SSTR2 antibody

SSTRs (for somatostatin receptors) represent a family of G-protein-coupled receptors which mediate the diverse biological actions of somatostatin (SST). There are five distinct subtypes of SSTRs that bind two natural ligands, SST-14 and SST-28. SSTR2 gives rise to spliced variants, SSTR2A and 2B. SSTRs share common signaling pathways such as the ability to inhibit adenylyl cyclase via GTP binding proteins. Some of the subtypes are also coupled to tyrosine phosphatase (SSTR1, 2), Ca2+ channels (SSTR2), Na+/H+ exchanger (SSTR1), PLA-2 (SSTR4), and MAP kinase (SSTR4). Individual target cells typically express more than one SSTR subtype and often all five isoforms. Subtypes of SSTR can form functional homo- and heterodimers.

NCBI and Uniprot Product Information

• NCBI GI #: 401126
• NCBI GeneID: 6752
• UniProt Accession #: P30874
• Molecular Weight: ~ 80kDa
• NCBI Official Full Name: Somatostatin receptor type 2
• NCBI Official Synonym Full Names: somatostatin receptor 2
• NCBI Official Symbol: SSTR2
• NCBI Protein Information: somatostatin receptor type 2
• UniProt Protein Name: Somatostatin receptor type 2
• Protein Family: Somatostatin receptor
• UniProt Gene Name: SSTR2
• UniProt Synonym Gene Names: SS-2-R; SS2-R; SS2R
• UniProt Entry Name: SSR2_HUMAN

NCBI Description

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

Uniprot Description

SSTR2: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. The C-terminus interacts with SHANK1 PDZ domain. Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: neuropeptide binding; protein binding; somatostatin receptor activity; PDZ domain binding

Biological Process: peristalsis; regulation of muscle contraction; response to starvation; synaptic transmission; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; neuropeptide signaling pathway; forebrain development; digestion; cerebellum development; spermatogenesis; G-protein signaling, adenylate cyclase inhibiting pathway; response to nutrient