Rabbit SRSF11 Polyclonal Antibody | anti-SRSF11 antibody

SRSF11 Polyclonal Antibody

Cat. Num. AAA3006207

• Gene Names: SRSF11; p54; NET2; SFRS11; dJ677H15.2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: SRSF11; Polyclonal Antibody; SRSF11 Polyclonal Antibody; Serine/arginine-rich splicing factor 11; Arginine-rich 54 kDa nuclear protein; p54; Splicing factor; arginine/serine-rich 11; SFRS11; anti-SRSF11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SRSF11 polyclonal antibody detects endogenous levels of SRSF11 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 483

• Applicable Applications for anti-SRSF11 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 260-305 of Human SRSF11.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of SRSF11 Antibody at 1:500 dilutionLane1:CT26 whole cell lysate (40ug) Lane2:H9C2 whole cell lysate (40ug) Lane3:SGC7901 whole cell lysate (40ug) Lane4:A549 whole cell lysate (40ug))

Related Product Information for anti-SRSF11 antibody

Pre-mRNA splicing enhancer elements are short RNA sequences capable of activating weak splice sites in nearby introns that are required for accurate splice site recognition and the control of alternative splicing. Splicing enhancer elements contain specific binding sites for serine/arginine (SR)-rich splicing factors, which include SC35, 9G8, SRp20 and SF2/ASF. The family of SR factors all contain one or more RNA recognition motifs (RRM) and a SR-rich domain. The SR factor family is not only essential for constitutive splicing, but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. SFRS11 (splicing factor, arginine/serine-rich 11), also known as arginine-rich 54 kDa nuclear protein (p54) or NET2, is a 484 amino acid nuclear protein that colocalizes with spliceosome components and belongs to the splicing factor SR family. SFRS11 may function in pre-mRNA splicing and contains one RRM (RNA recognition motif) domain.

NCBI and Uniprot Product Information

• NCBI GI #: 300244569
• NCBI GeneID: 9295
• NCBI Accession #: NP_001177916.1
• NCBI GenBank Nucleotide #: NP_001177916.1
• UniProt Accession #: Q05519
• Molecular Weight: ~ 54kDa
• NCBI Official Full Name: serine/arginine-rich splicing factor 11 isoform 2
• NCBI Official Synonym Full Names: serine and arginine rich splicing factor 11
• NCBI Official Symbol: SRSF11
• NCBI Official Synonym Symbols: p54; NET2; SFRS11; dJ677H15.2
• NCBI Protein Information: serine/arginine-rich splicing factor 11
• UniProt Protein Name: Serine/arginine-rich splicing factor 11
• Protein Family: Serine/arginine-rich splicing factor
• UniProt Gene Name: SRSF11
• UniProt Synonym Gene Names: SFRS11; p54
• UniProt Entry Name: SRS11_HUMAN

NCBI Description

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]

Uniprot Description

SRSF11: May function in pre-mRNA splicing. Belongs to the splicing factor SR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing; RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; nucleotide binding

Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription