Immunohistochemistry (IHC)
(Immunochemical staining of human SRRM4 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human SRRM4 Polyclonal Antibody | anti-SRRM4 antibody
Anti-SRRM4 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
SRRM4; Polyclonal Antibody; Anti-SRRM4 Antibody; Rabbit Polyclonal; SRRM4 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-KIAA1853 Antibody; Anti-nSR100 Antibody; anti-SRRM4 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human SRRM4
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-SRRM4 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human SRRM4 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human SRRM4 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human SRRM4 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human SRRM4 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-SRRM4 antibody
SRRM4 is a master regulator of neural-specific exon networks that are required for the differentiation of embryonic SC and neural progenitor cells during embryonic development. It exerts its actions by promoting the inclusion of neural-specific exons into the coding regions of target genes, therefore generating alterative protein isoforms necessary for remodeling protein-protein interactions networks and signaling pathways that are essential for neurogenesis and neuronal maturation and function. SRRM4 is specifically expressed in nervous tissue and cells. SRRM4 is a key factor in neural differentiation. SRRM4 may also regulate a pluripotency gene network in AdPC (prostate adenocarcinoma) cells with specific genetic and epigenetic backgrounds during t-NEPC (treatment-induced neuroendocrine prostate cancer) progression.
References
Shimojo M, et al. (2019) A gapmer antisense oligonucleotide targeting srrm4 is a novel therapeutic medicine for lung cancer. Sci Rep 9 (1): 7618.Ohnishi T, et al. (2017) Srrm4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth. Sci Rep 7 41130.Li Y, et al. (2017) Establishment of a neuroendocrine prostate cancer model driven by the rna splicing factor srrm4. Oncotarget 8 (40): 66878-66888.
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Product Notes
The SRRM4 (Catalog #AAA8110090) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SRRM4 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SRRM4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the SRRM4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SRRM4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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