Rabbit anti-Human SRMS Polyclonal Antibody | anti-SRMS antibody

SRMS Antibody (N-term)

Cat. Num. AAA9210688

• Gene Names: SRMS; SRM; C20orf148; dJ697K14.1
• Reactivity: Human
• Applications: Western Blot, ELISA, Immunohistochemistry
• Purity: Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: SRMS; Polyclonal Antibody; SRMS Antibody (N-term); Tyrosine-protein kinase Srms; C20orf148; anti-SRMS antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This SRMS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from the N-terminal region of human SRMS.
• Purity/Purification: Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Positions: 19-48
• Sequence Length: 488

• Applicable Applications for anti-SRMS antibody: Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis of anti-SRMS Antibody (N-term) in HL60 cell line lysates (35ug/lane). SRMS(arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)

Related Product Information for anti-SRMS antibody

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Product Categories/Family for anti-SRMS antibody

Signal Transduction

References

Kohmura, N., et al., Mol. Cell. Biol. 14(10):6915-6925 (1994).

NCBI and Uniprot Product Information

• NCBI GI #: 18250298
• NCBI GeneID: 6725
• NCBI Accession #: NP_543013.1
• NCBI GenBank Nucleotide #: NM_080823.3
• UniProt Accession #: Q9H3Y6
• Molecular Weight: 54507
• NCBI Official Full Name: tyrosine-protein kinase Srms
• NCBI Official Synonym Full Names: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
• NCBI Official Symbol: SRMS
• NCBI Official Synonym Symbols: SRM; C20orf148; dJ697K14.1
• NCBI Protein Information: tyrosine-protein kinase Srms
• UniProt Protein Name: Tyrosine-protein kinase Srms
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: SRMS
• UniProt Synonym Gene Names: C20orf148
• UniProt Entry Name: SRMS_HUMAN

Uniprot Description

SRMS: a tyrosine kinase of the Src family.

Protein type: Motility/polarity/chemotaxis; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; TK group; Src family

Chromosomal Location of Human Ortholog: -

Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: cell migration; innate immune response; cell differentiation; actin cytoskeleton organization and biogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation