Rabbit anti-Human SRGN Polyclonal Antibody | anti-SRGN antibody

SRGN Polyclonal Antibody

Cat. Num. AAA2527908

• Gene Names: SRGN; PPG; PRG; PRG1
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purification
• Synonyms: SRGN; Polyclonal Antibody; SRGN Polyclonal Antibody; PPG; PRG; PRG1; anti-SRGN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.05% sodium azide and 50% glycerol, pH 7.4
• Sequence Length: 158

• Applicable Applications for anti-SRGN antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25 - 1:100
• Immunogen: Recombinant protein of human SRGN
• Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Preparation and Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin embedded Human liver cancer tissue using SRGN Polyclonal Antibody at dilution 1:25)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffi nembedded Thymus tissue using SRGN Polyclonal Antibody at dilution of 1:100 (Detected by lifespan))

Related Product Information for anti-SRGN antibody

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.

Product Categories/Family for anti-SRGN antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 45935371
• NCBI GeneID: 5552
• NCBI Accession #: NP_002718.2
• NCBI GenBank Nucleotide #: NM_002727.2
• UniProt Accession #: P10124; Q5VW06; B2R4L7
• NCBI Official Full Name: serglycin
• NCBI Official Synonym Full Names: serglycin
• NCBI Official Symbol: SRGN
• NCBI Official Synonym Symbols: PPG; PRG; PRG1
• NCBI Protein Information: serglycin; hematopoetic proteoglycan core peptide; hematopoetic proteoglycan core protein; hematopoietic proteoglycan core protein; p.PG; platelet proteoglycan core protein; proteoglycan 1, secretory granule; proteoglycan protein core for mast cell secretory granule; secretory granule proteoglycan core peptide; secretory granule proteoglycan core protein; serglycin proteoglycan
• UniProt Protein Name: Serglycin
• Protein Family: Serglycin
• UniProt Gene Name: SRGN
• UniProt Synonym Gene Names: PRG; PRG1; P.PG
• UniProt Entry Name: SRGN_HUMAN

NCBI Description

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

SRGN: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. Belongs to the serglycin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; mast cell granule; extracellular region

Molecular Function: collagen binding; protein binding

Biological Process: maintenance of granzyme B localization in T cell secretory granule; negative regulation of bone mineralization; platelet activation; induction of apoptosis by granzyme; platelet degranulation; biomineral formation; negative regulation of cytokine secretion; T cell secretory granule organization and biogenesis; mast cell secretory granule organization and biogenesis; protein processing; maintenance of protease localization in mast cell secretory granule; blood coagulation