Rabbit srGAP2 Polyclonal Antibody | anti-SRGAP2 antibody
srGAP2 Antibody
Gene Names
SRGAP2; FNBP2; SRGAP3; SRGAP2A; ARHGAP34
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
srGAP2; Polyclonal Antibody; srGAP2 Antibody; ARHGAP34; FBP2; FNBP2; FNBP2_HUMAN; Formin binding protein 2; Formin-binding protein 2; Rho GTPase-activating protein 34; SLIT ROBO Rho GTPase activating protein 2; SLIT-ROBO Rho GTPase-activating protein 2; SRGAP3; anti-SRGAP2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
srGAP2 Antibody detects endogenous levels of total srGAP2.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SRGAP2 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Similarity
The F-BAR domain mediates oligomerization, binds membranes, and induces plasma membrane protrusions.
Post Translational Modifications
Methylation at Arg-927 is required for the stimulation of cell migration, dimerization and localization at the plasma membrane protrusions.
Subunit Structure
Homodimer (Probable). Forms a heterooligomer with SRGAP1 and SRGAP3 through its F-BAR domain. Interacts (via SH3 domain) with GPHN (By similarity). Interacts with SRGAP2C; formation of the heterodimer alters SRGAP2 function. Interacts (via SH3 domain) with FMNL1 (activated by RAC1); regulates the actin filament severing activity of FMNL1 and actin dynamics. Interacts (via SH3 domain) with FMNL3. Interacts with RAC1; specifically stimulates RAC1 GTPase activity. Probably interacts with ROBO1 and ROBO2. Interacts with FASLG. Interacts with PRMT5.
Function
RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
Note
Recruited to actin-rich phagosomes during phagocytosis. Translocates from nucleus to cytoplasm during development.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-SRGAP2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
120,881 Da
NCBI Official Full Name
SLIT-ROBO Rho GTPase-activating protein 2 isoform c
NCBI Official Synonym Full Names
SLIT-ROBO Rho GTPase activating protein 2
NCBI Official Symbol
SRGAP2
NCBI Official Synonym Symbols
FNBP2; SRGAP3; SRGAP2A; ARHGAP34
NCBI Protein Information
SLIT-ROBO Rho GTPase-activating protein 2; SLIT-ROBO GAP2; formin-binding protein 2; rho GTPase-activating protein 34
UniProt Protein Name
SLIT-ROBO Rho GTPase-activating protein 2
Protein Family
UniProt Gene Name
SRGAP2
UniProt Synonym Gene Names
ARHGAP34; FNBP2; KIAA0456; SRGAP2A; srGAP2
UniProt Entry Name
SRGP2_HUMAN
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Product Notes
The SRGAP2 srgap2 (Catalog #AAA9629175) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The srGAP2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's srGAP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the SRGAP2 srgap2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "srGAP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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