Rabbit anti-Human SRFBP1 Polyclonal Antibody | anti-SRFBP1 antibody
Anti-SRFBP1 Antibody, Rabbit Polyclonal
Gene Names
SRFBP1; P49; Rlb1; BUD22; STRAP; p49/STRAP
Reactivity
Human
Applications
Western Blot, Immunoprecipitation
Purity
Protein A & Antigen Affinity
Synonyms
SRFBP1; Polyclonal Antibody; Anti-SRFBP1 Antibody; Rabbit Polyclonal; SRFBP1 (p49/STRAP) Antibody; Rabbit PAb; Antigen Affinity Purified; serum response factor binding protein 1; Anti-BUD22 Antibody; Anti-P49 Antibody; Anti-p49/STRAP Antibody; Anti-Rlb1 Antibody; Anti-STRAP Antibody; anti-SRFBP1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human SRFBP1 (p49/STRAP)
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-SRFBP1 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes
WB: 1:500-1:2000
IP: 1-4uL/mg of lysate
IP: 1-4uL/mg of lysate
Immunogen
Recombinant Human SRFBP1 (p49/STRAP) protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Human SRFBP1 (p49/STRAP) (rh SRFBP1 (p49/STRAP)). SRFBP1 (p49/STRAP) specific IgG was purified by Human SRFBP1 (p49/STRAP) affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-SRFBP1 antibody
SRFBP1 contains 7 WD repeats and belongs to the WD repeat STRAP family. SRFBP1 may play a role in the cellular distribution of the SMN complex. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. SRFBP1 negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. SRFBP1 may be involved in regulating transcriptional activation of cardiac genes during the aging process. It also may play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
References
Datta PK, et al. (1999) Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem. 273(52):34671-4.Datta PK, et al. (1998) Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem. 273(52):34671-4.Datta PK, et al. (2000) STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Mol Cell Biol. 20(9):3157-67.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
48,634 Da
NCBI Official Full Name
SRFBP1 protein, partial
NCBI Official Synonym Full Names
serum response factor binding protein 1
NCBI Official Symbol
SRFBP1
NCBI Official Synonym Symbols
P49; Rlb1; BUD22; STRAP; p49/STRAP
NCBI Protein Information
serum response factor-binding protein 1
UniProt Protein Name
Serum response factor-binding protein 1
Protein Family
UniProt Gene Name
SRFBP1
Uniprot Description
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells ().
Research Articles on SRFBP1
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Product Notes
The SRFBP1 srfbp1 (Catalog #AAA8107355) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SRFBP1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SRFBP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). WB: 1:500-1:2000 IP: 1-4uL/mg of lysate. Researchers should empirically determine the suitability of the SRFBP1 srfbp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SRFBP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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