Goat SRCAP Polyclonal Antibody | anti-SRCAP antibody
Goat anti-SRCAP Antibody
Western Blot: Preliminary experiments in lysates of cell lines K562 and MOLT4 gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
Uniprot Description
SRCAP: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Defects in SRCAP are the cause of Floating-Harbor syndrome (FLHS). A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.4.-; Transcription, coactivator/corepressor; Helicase; EC 3.6.1.-; DNA-binding; Acetyltransferase
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: Golgi apparatus; nucleus; perinuclear region of cytoplasm; protein complex
Molecular Function: ATP binding; DNA binding; helicase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity
Biological Process: histone acetylation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction
Disease: Floating-harbor Syndrome
Research Articles on SRCAP
Similar Products
Product Notes
The SRCAP srcap (Catalog #AAA421768) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-SRCAP Antibody reacts with Expected from sequence similarity: Human, Mouse, Rat, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's SRCAP can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Preliminary experiments in lysates of cell lines K562 and MOLT4 gave no specific signal but low background (at antibody concentration up to 1ug/ml). Researchers should empirically determine the suitability of the SRCAP srcap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: DEAQNIKNFK SQR. It is sometimes possible for the material contained within the vial of "SRCAP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
