Rabbit anti-Human SRA1 Polyclonal Antibody | anti-SRA1 antibody

SRA1 Rabbit Polyclonal

Cat. Num. AAA7604445

• Gene Names: SRA1; SRA; SRAP; STRAA1; pp7684
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SRA1; Polyclonal Antibody; SRA1 Rabbit Polyclonal; anti-SRA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 208

• Applicable Applications for anti-SRA1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Steroid receptor RNA activator 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(MCF-7 cells were subjected to SDS PAGE followed by western blot with MBS7604445 (SRA1 Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 359338964
• NCBI GeneID: 10011
• NCBI Accession #: NP_001240693.1
• NCBI GenBank Nucleotide #: NM_001253764.1
• Molecular Weight: 25,673 Da
• NCBI Official Full Name: steroid receptor RNA activator 1 isoform 2
• NCBI Official Synonym Full Names: steroid receptor RNA activator 1
• NCBI Official Symbol: SRA1
• NCBI Official Synonym Symbols: SRA; SRAP; STRAA1; pp7684
• NCBI Protein Information: steroid receptor RNA activator 1
• UniProt Protein Name: Steroid receptor RNA activator 1
• Protein Family: Steroid receptor RNA activator
• UniProt Gene Name: SRA1
• UniProt Synonym Gene Names: SRAP
• UniProt Entry Name: SRA1_HUMAN

NCBI Description

Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]

Uniprot Description

SRA1: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. Belongs to the SRA1 family.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: cytoplasm; intercellular bridge; microtubule cytoskeleton; nucleoplasm; nucleus; plasma membrane; ribonucleoprotein complex

Molecular Function: ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; transcription coactivator activity

Biological Process: apoptosis; cell differentiation; cell proliferation; regulation of apoptosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent