Rabbit anti-Human SPSB2 Polyclonal Antibody | anti-SPSB2 antibody

SPSB2 (SPRY Domain-containing SOCS Box Protein 2, SSB2, SSB-2, Gene-rich Cluster Protein C9, GRCC9) (PE)

Cat. Num. AAA6395036

• Gene Names: SPSB2; SSB2; GRCC9
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SPSB2; Polyclonal Antibody; SPSB2 (SPRY Domain-containing SOCS Box Protein 2; SSB2; SSB-2; Gene-rich Cluster Protein C9; GRCC9) (PE); FLJ17395; MGC2519; anti-SPSB2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SPSB2.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-SPSB2 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human SPSB2, aa1-263 (NP_116030.1).
• Immunogen Sequence: MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of SPSB2 expression in transfected 293T cell line by SPSB2 polyclonal antibody. Lane 1: SPSB2 transfected lysate (28.6kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-SPSB2 antibody

Antibodies; SOCS

NCBI and Uniprot Product Information

• NCBI GI #: 14249178
• NCBI GeneID: 84727
• NCBI Accession #: NP_116030.1
• NCBI GenBank Nucleotide #: NM_032641
• UniProt Accession #: Q99619; B7Z4W1; D3DUT0
• Molecular Weight: 28,642 Da
• NCBI Official Full Name: SPRY domain-containing SOCS box protein 2
• NCBI Official Synonym Full Names: splA/ryanodine receptor domain and SOCS box containing 2
• NCBI Official Symbol: SPSB2
• NCBI Official Synonym Symbols: SSB2; GRCC9
• NCBI Protein Information: SPRY domain-containing SOCS box protein 2; gene-rich cluster protein C9; SPRY domain-containing SOCS box protein SSB-2
• UniProt Protein Name: SPRY domain-containing SOCS box protein 2
• Protein Family: SPRY domain-containing SOCS box protein
• UniProt Gene Name: SPSB2
• UniProt Synonym Gene Names: GRCC9; SSB2; SSB-2
• UniProt Entry Name: SPSB2_HUMAN

NCBI Description

This gene encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Uniprot Description

SPSB2: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Belongs to the SPSB family.

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: protein ubiquitination