Western Blot (WB)
(SPPL2B antibody (MBS839114) used at 1 ug/ml to detect target protein.)
Rabbit SPPL2B Polyclonal Antibody | anti-SPPL2B antibody
SPPL2B antibody
IHC: 4-8 ug/ml
Western Blot (WB)
(SPPL2B antibody (MBS839114) used at 1 ug/ml to detect target protein.)
Western Blot (WB)
(SPPL2B antibody (MBS839114) used at 1 ug/ml to detect target protein.)
Immunohistochemistry (IHC)
(SPPL2B antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X)
Immunohistochemistry (IHC)
(SPPL2B antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
SPPL2B: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Belongs to the peptidase A22B family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; EC 3.4.23.-; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: lysosomal membrane; plasma membrane; endosome membrane
Molecular Function: protein binding; protein homodimerization activity; aspartic endopeptidase activity, intramembrane cleaving
Biological Process: regulation of immune response; membrane protein intracellular domain proteolysis; membrane protein ectodomain proteolysis
Research Articles on SPPL2B
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Product Notes
The SPPL2B sppl2b (Catalog #AAA839114) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPPL2B antibody reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rat. and may cross-react with other species as described in the data sheet. AAA Biotech's SPPL2B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1 ug/ml IHC: 4-8 ug/ml. Researchers should empirically determine the suitability of the SPPL2B sppl2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPPL2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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