Western Blot (WB)
(The anti-SPPL2a Pab is used in Western blot to detect SPPL2a in Jurkat cell lysate.)
Rabbit anti-Human SPPL2a Polyclonal Antibody | anti-SPPL2a antibody
SPPL2a, NT (Signal Peptide Peptidase-like 2A, SPP-like 2A, SPPL2a, Intramembrane Protease 3, IMP-3, Presenilin-like Protein 2, IMP3, PSL2, PSEC0147) (AP)
ELISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.
Western Blot (WB)
(The anti-SPPL2a Pab is used in Western blot to detect SPPL2a in Jurkat cell lysate.)
Western Blot (WB)
(The anti-SPPL2a Pab is used in Western blot to detect SPPL2a in Jurkat cell lysate.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2a Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2a Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the signal peptide peptidase-like protease (SPPL) family and encodes an endosomal membrane protein with a protease associated (PA) domain. This protein plays a role in innate and adaptive immunity. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq]
Uniprot Description
SPPL2A: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. Belongs to the peptidase A22B family.
Protein type: EC 3.4.23.-; Membrane protein, multi-pass; Cancer Testis Antigen (CTA); Protease; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component: lysosomal membrane; late endosome membrane; plasma membrane
Molecular Function: protein binding; protein homodimerization activity; aspartic-type endopeptidase activity
Biological Process: regulation of immune response; membrane protein intracellular domain proteolysis; membrane protein ectodomain proteolysis
Research Articles on SPPL2a
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Product Notes
The SPPL2a sppl2a (Catalog #AAA6500601) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPPL2a, NT (Signal Peptide Peptidase-like 2A, SPP-like 2A, SPPL2a, Intramembrane Protease 3, IMP-3, Presenilin-like Protein 2, IMP3, PSL2, PSEC0147) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPPL2a can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB). IHC: 1:10-1:50 ELISA: 1:1,000 WB: 1:100-1:500 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SPPL2a sppl2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPPL2a, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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