Rabbit Splicing Factor, Arginine/Serine-Rich 12 Polyclonal Antibody | anti-SREK1 antibody

Splicing Factor, Arginine/Serine-Rich 12 (SFRS12, Serine/Arginine-Rich Splicing Regulatory Protein 86, SRrp86, Splicing Regulatory Protein 508, SRrp508)

Cat. Num. AAA614954

• Gene Names: SREK1; SFRS12; SRrp86; SRrp508
• Reactivity: Human, Rodent
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Splicing Factor; Arginine/Serine-Rich 12; Polyclonal Antibody; Arginine/Serine-Rich 12 (SFRS12; Serine/Arginine-Rich Splicing Regulatory Protein 86; SRrp86; Splicing Regulatory Protein 508; SRrp508); Anti -Splicing Factor; anti-SREK1 antibody

• Host: Rabbit
• Reactivity: Human, Rodent
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Splicing Factor, Arginine/Serine-Rich 12.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 40% glycerol.

• Applicable Applications for anti-SREK1 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA (serum titer): 1:1375,000; Western Blot: Preliminary results: MCF7 cells 110kD, Human breast 70kD (Weak); Immunohistochemistry: 5ug/ml
• Immunogen: Synthetic peptide aa409-424, PRSRNKKDKKREKERD of human SFRS12 (KLH). MW: 59,380kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-SREK1 antibody

Antibodies; Abs to Splicing Factors

NCBI and Uniprot Product Information

• NCBI GI #: 395455051
• NCBI GeneID: 140890
• NCBI Accession #: NP_001257421.1
• NCBI GenBank Nucleotide #: NM_001270492.1
• UniProt Accession #: Q8WXA9; Q2M1J0; Q86X37; A4FTW3
• Molecular Weight: 59,380 Da
• NCBI Official Full Name: splicing regulatory glutamine/lysine-rich protein 1 isoform c
• NCBI Official Synonym Full Names: splicing regulatory glutamine/lysine-rich protein 1
• NCBI Official Symbol: SREK1
• NCBI Official Synonym Symbols: SFRS12; SRrp86; SRrp508
• NCBI Protein Information: splicing regulatory glutamine/lysine-rich protein 1; splicing regulatory protein 508; splicing factor, arginine/serine-rich 12; serine/arginine-rich-splicing regulatory protein 86; serine-arginine-rich splicing regulatory protein 508
• UniProt Protein Name: Splicing regulatory glutamine/lysine-rich protein 1
• Protein Family: Splicing regulatory glutamine/lysine-rich protein
• UniProt Gene Name: SREK1
• UniProt Synonym Gene Names: SFRS12; SRRP86; SRrp86; SRrp508
• UniProt Entry Name: SREK1_HUMAN

NCBI Description

This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

SFRS12: Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3. Belongs to the splicing factor SR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; RNA processing

Chromosomal Location of Human Ortholog: 5q12.3

Cellular Component: nucleoplasm; spliceosome

Molecular Function: nucleotide binding

Biological Process: RNA splicing; mRNA processing