Rabbit anti-Human Sphingosine 1 Phosphate 3 Receptor (EDG-3) NT Polyclonal Antibody | anti-EDG-3 antibody

Sphingosine 1 Phosphate 3 Receptor (EDG-3) NT

Cat. Num. AAA396001

• Gene Names: S1PR3; EDG3; LPB3; S1P3; EDG-3
• Reactivity: Human
• Applications: Western Blot
• Purity: Ammonium Sulfate Precipitation
• Synonyms: Sphingosine 1 Phosphate 3 Receptor (EDG-3) NT; Polyclonal Antibody; Endothelial cell differentiation gene 3 N-terminal; Sphingosine-1-Phosphate Receptor-3 (S1P3); anti-EDG-3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Ammonium Sulfate Precipitation
• Form/Format: Provided as solution in phosphate buffered saline with 0.08% sodium azide
• Sequence Length: 378

• Applicable Applications for anti-EDG-3 antibody: Western Blot (WB)
• Immunogen: Synthetic peptide derived from the N terminal of the EDG3 (S1P3) protein.
• Positive Control: RH7777 cells transfected with EDG3 (S1P3) protein
• Preparation and Storage: Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Related Product Information for anti-EDG-3 antibody

Endothelial cell differentation gene-3 (EDG3) belongs to a family of G-protein couple receptors whose ligands are lysophospholipids. The ligand for EDG3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family. They have been implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG3 is expressed in cardiovascular, leukocyte-containing and other tissues.

Product Categories/Family for anti-EDG-3 antibody

Polyclonal Antibody; G Protein-Coupled Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 38788193
• NCBI GeneID: 1903
• NCBI Accession #: NP_005217.2
• NCBI GenBank Nucleotide #: NM_005226.3
• UniProt Accession #: Q99500; Q5SQD8; Q7Z5I2
• Molecular Weight: 42,250 Da
• NCBI Official Full Name: sphingosine 1-phosphate receptor 3
• NCBI Official Synonym Full Names: sphingosine-1-phosphate receptor 3
• NCBI Official Symbol: S1PR3
• NCBI Official Synonym Symbols: EDG3; LPB3; S1P3; EDG-3
• NCBI Protein Information: sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; sphingosine 1-phosphate receptor Edg-3; endothelial differentiation G-protein coupled receptor 3; G protein-coupled receptor, endothelial differentiation gene-3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
• UniProt Protein Name: Sphingosine 1-phosphate receptor 3
• UniProt Gene Name: S1PR3
• UniProt Synonym Gene Names: EDG3; S1P receptor 3; S1P3
• UniProt Entry Name: S1PR3_HUMAN

NCBI Description

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Ref.9

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.