Western Blot/Blotting
(Detection of 20 ng/lane recombinant SMSr using X1861P (1.25 ug/ml) and anti-rabbit HRP (1:200k) and using Pierce?s Super Signal West Femto.)
Rabbit anti-Drosphila Sphingomyelin synthase-related protein 1 Polyclonal Antibody | anti-SMSr antibody
Sphingomyelin synthase-related protein 1
Gene Names
SMSr; CG32380; CG8572; CG8576; Css3beta; DmelCG32380; dmSMSr; dSMSr
Reactivity
Drosphila
Applications
Western Blot
Purity
Ammonium Sulfate Precipitation
Synonyms
Sphingomyelin synthase-related protein 1; Polyclonal Antibody; SMSr; anti-SMSr antibody
Host
Rabbit
Reactivity
Drosphila
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Ammonium Sulfate Precipitation
Form/Format
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Sequence Length
600
Applicable Applications for anti-SMSr antibody
Western Blot (WB)
Immunogen
Recombinant SMSr derived from Drosophila.
Positive Control
Recombinant sphingomelin synthase protein
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Western Blot/Blotting
(Detection of 20 ng/lane recombinant SMSr using X1861P (1.25 ug/ml) and anti-rabbit HRP (1:200k) and using Pierce?s Super Signal West Femto.)
Western Blot/Blotting
(Detection of 20 ng/lane recombinant SMSr using X1861P (1.25 ug/ml) and anti-rabbit HRP (1:200k) and using Pierce?s Super Signal West Femto.)
Related Product Information for anti-SMSr antibody
Sphingomyelin synthases are enzymes that mediate the biosynthesis of sphingolipid headgroups. Sphingomyelin synthase 1 and 2 (SMS1 and SMS2) mediate the biosynthesis of sphingomyelin, a central sphingolipid in mammalian cells. In addition to SMS1 and SMS2, a third SMS-related protein, SMSr, is known, however its function remains largely unknown. SMSr also occurs in organisms which lack sphingomyelin, such as the fruit fly Drosophila melanogaster. Its function appears to be biosynthesis of ethanolamine phosphorylceramide (EPC), a sphingolipid structurally related to sphingomyelin. SMSr has also been found in mammals as well.
Product Categories/Family for anti-SMSr antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
67,063 Da
NCBI Official Full Name
SMSr, isoform A
NCBI Official Symbol
SMSr
NCBI Official Synonym Symbols
CG32380; CG8572; CG8576; Css3beta; DmelCG32380; dmSMSr; dSMSr
NCBI Protein Information
CG32380 gene product from transcript CG32380-RA; CG32380-PA; CG32380-PB; CPE synthase; SMSr; SMSr-PA; SMSr-PB
UniProt Protein Name
Sphingomyelin synthase-related 1
Protein Family
UniProt Gene Name
SMSr
UniProt Synonym Gene Names
CPE synthase
UniProt Entry Name
SMSR1_DROME
Uniprot Description
Function: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. Ref.6
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.6.
Domain: The SAM domain is required to retain SMSR in the endoplasmic reticulum
By similarity.
Sequence similarities: Belongs to the sphingomyelin synthase family.Contains 1 SAM (sterile alpha motif) domain.
Similar Products
Product Notes
The SMSr smsr (Catalog #AAA395540) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Sphingomyelin synthase-related protein 1 reacts with Drosphila and may cross-react with other species as described in the data sheet. AAA Biotech's Sphingomyelin synthase-related protein 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the SMSr smsr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sphingomyelin synthase-related protein 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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