Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis tissue slide using MBS7604382 (SPANXA2 Antibody) at dilution of 1:50)
Rabbit anti-Human SPANXA2/SPANXA1 Polyclonal Antibody | anti-SPANXA2/SPANXA1 antibody
SPANXA2/SPANXA1 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis tissue slide using MBS7604382 (SPANXA2 Antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis tissue slide using MBS7604382 (SPANXA2 Antibody) at dilution of 1:50)
Western Blot (WB)
(DU 145 cells were subjected to SDS PAGE followed by western blot with MBS7604382 (SPANXA2 antibody) at dilution of 1:500)
Western Blot (WB)
(DU 145 cells were subjected to SDS PAGE followed by western blot with MBS7604382 (SPANXA2 antibody) at dilution of 1:500)
NCBI and Uniprot Product Information
NCBI Description
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
Uniprot Description
SPANXA1: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
Protein type: Cancer Testis Antigen (CTA); Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq27.1
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: spermatogenesis
Research Articles on SPANXA2/SPANXA1
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Product Notes
The SPANXA2/SPANXA1 spanxa1 (Catalog #AAA7604382) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPANXA2/SPANXA1 Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPANXA2/SPANXA1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the SPANXA2/SPANXA1 spanxa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPANXA2/SPANXA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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