Rabbit anti-Human SOX8 Polyclonal Antibody | anti-SOX8 antibody

SOX8, ID (SOX8, Transcription factor SOX-8) (MaxLight 650)

Cat. Num. AAA6350104

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: SOX8; Polyclonal Antibody; ID (SOX8; Transcription factor SOX-8) (MaxLight 650); Transcription factor SOX-8; anti-SOX8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SOX8.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-SOX8 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 225-253 in the central region of human SOX8, UniProt Accession #P57073.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of SK-BR-3 cell line lysates (35ug/lane) usingMBS6001320. This demonstrates that MBS6001320 detected the SOX8 protein (arrow).)

Related Product Information for anti-SOX8 antibody

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).

Product Categories/Family for anti-SOX8 antibody

Antibodies; Transcription Factors

References

1. Nonaka, D. Am. J. Clin. Pathol. 131(5):731-736(2009). 2. Hoff, S., et al. J. Comp. Neurol. 509(4):356-371(2008). 3. Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006). 4. Schepers, G., et al. J. Biol. Chem. 278(30):28101-28108(2003). 5. Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 30179903
• NCBI GeneID: 30812
• NCBI Accession #: NP_055402.2
• NCBI GenBank Nucleotide #: NM_014587.4
• UniProt Accession #: P57073; Q9NZW2
• Molecular Weight: 47,314 Da
• NCBI Official Full Name: transcription factor SOX-8
• NCBI Official Synonym Full Names: SRY-box 8
• NCBI Official Symbol: SOX8
• NCBI Protein Information: transcription factor SOX-8
• UniProt Protein Name: Transcription factor SOX-8
• Protein Family: Transcription factor
• UniProt Gene Name: SOX8
• UniProt Entry Name: SOX8_HUMAN

NCBI Description

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008]

Uniprot Description

SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; nucleus

Molecular Function: DNA binding; protein heterodimerization activity; transcription factor binding

Biological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis