Rabbit SOX6 Polyclonal Antibody | anti-SOX6 antibody

SOX6 Conjugated Antibody

Cat. Num. AAA9455745

• Gene Names: SOX6; SOXD; HSSOX6
• Reactivity: Human, Mouse, Rat
• Applications: Most Applications
• Synonyms: SOX6; Polyclonal Antibody; SOX6 Conjugated Antibody; Transcription factor SOX-6; anti-SOX6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of SOX6 protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-SOX6 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human SOX6.
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

NCBI and Uniprot Product Information

• NCBI GI #: 224967050
• NCBI GeneID: 55553
• NCBI Accession #: NP_001139283.1
• NCBI GenBank Nucleotide #: NM_001145811.1
• UniProt Accession #: P35712; Q86VX7; Q9BXQ3; Q9BXQ4; Q9BXQ5; Q9H0I8
• Molecular Weight: 91,921 Da
• NCBI Official Full Name: transcription factor SOX-6 isoform 3
• NCBI Official Synonym Full Names: SRY (sex determining region Y)-box 6
• NCBI Official Symbol: SOX6
• NCBI Official Synonym Symbols: SOXD; HSSOX6
• NCBI Protein Information: transcription factor SOX-6; SRY-box containing gene 6
• UniProt Protein Name: Transcription factor SOX-6
• Protein Family: Transcription factor
• UniProt Gene Name: SOX6
• UniProt Entry Name: SOX6_HUMAN

NCBI Description

This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Uniprot Description

SOX6: Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 11p15.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: muscle development; erythrocyte development; transcription, DNA-dependent; in utero embryonic development; cell morphogenesis; gene silencing; negative regulation of transcription from RNA polymerase II promoter; oligodendrocyte cell fate specification; cardiac muscle cell differentiation; post-embryonic development; positive regulation of chondrocyte differentiation; regulation of transcription, DNA-dependent; astrocyte differentiation; cartilage development; positive regulation of transcription from RNA polymerase II promoter