Rabbit anti-Human SOSTDC1 Polyclonal Antibody | anti-SOSTDC1 antibody

Anti-SOSTDC1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8101246

• Gene Names: SOSTDC1; USAG1; CDA019; ECTODIN
• Reactivity: Human
• Applications: Western Blot
• Purity: Protein A & Antigen Affinity
• Synonyms: SOSTDC1; Polyclonal Antibody; Anti-SOSTDC1 Antibody; Rabbit Polyclonal; SOSTDC1 Antibody; Rabbit PAb; Antigen Affinity Purified; sclerostin domain containing 1; Anti-CDA019 Antibody; Anti-ECTODIN Antibody; Anti-USAG1 Antibody; anti-SOSTDC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human SOSTDC1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-SOSTDC1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the C-terminus of the Human SOSTDC1
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human SOSTDC1, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Anti-SOSTDC1 rabbit polyclonal antibody at 1:500 dilution.Lane A: Mouse liver tissue lysate Lysates/proteins at 30 ug per lane.SecondaryGoat Anti- Rabbit  IgG H&L (Dylight 800)  at 1/10000 dilution.Developed using the Odyssey technique. Performed under reducing conditions.Predicted band size:23 kDaObserved band size:26 kDa)

Related Product Information for anti-SOSTDC1 antibody

The sclerostin domain containing protein 1 (SOSTDC1) is a cell signaling regulator involved in cell physiology and pathology. SOSTDC1 exerted its tumor suppressor function by inhibiting the activity of major signaling pathways including the phosphatidylinositol-3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK)/Erk pathways. SOSTDC1 might represent a tumor suppressor through inhibiting the proliferation of NSCLC cells by regulating p21Cip and p27Kip, which in turn affects Rb-E2F signaling. SOSTDC1 is down-regulated in thyroid cancer and might be a potential therapeutic target in the treatment of thyroid cancer.

NCBI and Uniprot Product Information

• NCBI GI #: 23943785
• NCBI GeneID: 25928
• NCBI Accession #: NP_056279.1
• NCBI GenBank Nucleotide #: NM_015464.2
• UniProt Accession #: Q6X4U4; Q96HJ7; Q9Y3U3; A8MUA6
• Molecular Weight: 26,260 Da
• NCBI Official Full Name: sclerostin domain-containing protein 1
• NCBI Official Synonym Full Names: sclerostin domain containing 1
• NCBI Official Symbol: SOSTDC1
• NCBI Official Synonym Symbols: USAG1; CDA019; ECTODIN
• NCBI Protein Information: sclerostin domain-containing protein 1; cystine-knot containing secreted protein; ectodermal BMP inhibitor; uterine sensitization-associated protein-1
• UniProt Protein Name: Sclerostin domain-containing protein 1
• Protein Family: Sclerostin domain-containing protein
• UniProt Gene Name: SOSTDC1
• UniProt Synonym Gene Names: USAG1; Ectodin; USAG-1
• UniProt Entry Name: SOSD1_HUMAN

NCBI Description

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]

Uniprot Description

SOSTDC1: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Belongs to the sclerostin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: extracellular space

Biological Process: hair follicle morphogenesis; Wnt receptor signaling pathway; pattern specification process; odontogenesis of dentine-containing teeth; negative regulation of BMP signaling pathway; negative regulation of cell fate commitment