Rabbit anti-Human, Mouse SOSTDC1 Polyclonal Antibody | anti-SOSTDC1 antibody

SOSTDC1, CT (SOSTDC1, USAG1, Sclerostin domain-containing protein 1, Ectodermal BMP inhibitor, Uterine sensitization-associated gene 1 protein) (Biotin)

Cat. Num. AAA6349883

• Gene Names: SOSTDC1; USAG1; CDA019; ECTODIN
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SOSTDC1; Polyclonal Antibody; CT (SOSTDC1; USAG1; Sclerostin domain-containing protein 1; Ectodermal BMP inhibitor; Uterine sensitization-associated gene 1 protein) (Biotin); Uterine sensitization-associated gene 1 protein; anti-SOSTDC1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-SOSTDC1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SOSTDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-196 amino acids from the C-terminal region of human SOSTDC1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SOSTDC1 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SOSTDC1 antibody detected the SOSTDC1 protein (arrow).)

Western Blot (WB)

(SOSTDC1 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the SOSTDC1 antibody detected the SOSTDC1 protein (arrow).)

Related Product Information for anti-SOSTDC1 antibody

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.

Product Categories/Family for anti-SOSTDC1 antibody

Antibodies; Proteins

References

Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010): Ohshima, J., et al. Genes Chromosomes Cancer 48(12):1037-1050(2009). Blish, K.R., et al. Mol. Biol. Cell 19(2):457-464(2008). Lamesch, P., et al. Genomics 89(3):307-315(2007). Yanagita, M. Cytokine Growth Factor Rev. 16(3):309-317(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 23943785
• NCBI GeneID: 25928
• NCBI Accession #: NP_056279.1
• NCBI GenBank Nucleotide #: NM_015464.2
• UniProt Accession #: Q6X4U4; Q96HJ7; Q9Y3U3; A8MUA6
• Molecular Weight: 26,260 Da
• NCBI Official Full Name: sclerostin domain-containing protein 1
• NCBI Official Synonym Full Names: sclerostin domain containing 1
• NCBI Official Symbol: SOSTDC1
• NCBI Official Synonym Symbols: USAG1; CDA019; ECTODIN
• NCBI Protein Information: sclerostin domain-containing protein 1; cystine-knot containing secreted protein; ectodermal BMP inhibitor; uterine sensitization-associated protein-1
• UniProt Protein Name: Sclerostin domain-containing protein 1
• Protein Family: Sclerostin domain-containing protein
• UniProt Gene Name: SOSTDC1
• UniProt Synonym Gene Names: USAG1; Ectodin; USAG-1
• UniProt Entry Name: SOSD1_HUMAN

NCBI Description

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]

Uniprot Description

SOSTDC1: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Belongs to the sclerostin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: extracellular space

Biological Process: hair follicle morphogenesis; Wnt receptor signaling pathway; pattern specification process; odontogenesis of dentine-containing teeth; negative regulation of BMP signaling pathway; negative regulation of cell fate commitment