Immunohistochemistry (IHC)
((2.5ug/ml) staining of paraffin embedded human skeletal muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)
Goat SORBS1/Ponsin Polyclonal Antibody | anti-SORBS1 antibody
Goat anti-SORBS1/Ponsin (C Terminus) Antibody
Immunohistochemistry: In paraffin embedded Human Skeletal Muscle shows spotty staining on muscle fibres in longitudinal section. Recommended concentration, 2.5ug/ml. Data obtained from a previous batch.
Western Blot: No signal obtained yet but low background observed in human heart and 293 lysates at up to 2ug/ml.
Immunohistochemistry (IHC)
((2.5ug/ml) staining of paraffin embedded human skeletal muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)
Immunohistochemistry (IHC)
((2.5ug/ml) staining of paraffin embedded human skeletal muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Description
SORBS1: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. 12 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: cell-cell adherens junction; cell-substrate adherens junction; centrosome; cytoplasm; cytosol; focal adhesion; lipid raft; nucleoplasm; nucleus; plasma membrane; stress fiber; zonula adherens
Molecular Function: actin binding; cytoskeletal protein binding; insulin receptor binding; protein binding; SH3/SH2 adaptor activity
Biological Process: cell-matrix adhesion; cellular response to insulin stimulus; focal adhesion formation; glucose transport; insulin receptor signaling pathway; muscle contraction; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of lipid biosynthetic process; stress fiber formation
Research Articles on SORBS1
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Product Notes
The SORBS1 sorbs1 (Catalog #AAA421322) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-SORBS1/Ponsin (C Terminus) Antibody reacts with Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's SORBS1/Ponsin can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Immunohistochemistry (IHC). Peptide ELISA: Antibody detection limit dilution 1: 16000. Immunohistochemistry: In paraffin embedded Human Skeletal Muscle shows spotty staining on muscle fibres in longitudinal section. Recommended concentration, 2.5ug/ml. Data obtained from a previous batch. Western Blot: No signal obtained yet but low background observed in human heart and 293 lysates at up to 2ug/ml. Researchers should empirically determine the suitability of the SORBS1 sorbs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: GTFPGNYVKP LYL. It is sometimes possible for the material contained within the vial of "SORBS1/Ponsin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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