Flow Cytometry (FC/FACS)
Rabbit anti-Human SORBS1 Polyclonal Antibody | anti-SORBS1 antibody
Anti-SORBS1 Antibody
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
IHC-P (Embedded Section): 0.5-1ug/ml (Human)
FC/FACS: 1-3ug/1x106 cells (Human)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.
Flow Cytometry (FC/FACS)
Flow Cytometry (FC/FACS)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Western Blot (WB)
(Figure 1. Western blot analysis of SORBS1 using anti-SORBS1 antibody.)
Western Blot (WB)
(Figure 1. Western blot analysis of SORBS1 using anti-SORBS1 antibody.)
Background: CAP/Ponsinprotein, also known as Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SORBS1 gene. It is mapped to 10q24.1. This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants.
2. Mastick, C. C., Brady, M. J., Saltiel, A. R. Insulin stimulates the tyrosine phosphorylation of caveolin. J. Cell Biol. 129: 1523-1531, 1995.
3. Ribon, V., Printen, J. A., Hoffman, N. G., Kay, B. K., Saltiel, A. R. A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Molec. Cell. Biol. 18: 872-879, 1998.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Description
SORBS1: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. 12 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: centrosome; nuclear matrix; focal adhesion; zonula adherens; cytosol; cell-substrate adherens junction; lipid raft; nucleoplasm; cell-cell adherens junction; cytoplasm; plasma membrane; stress fiber; nucleus
Molecular Function: protein binding; SH3/SH2 adaptor activity; cytoskeletal protein binding; actin binding; protein kinase binding; insulin receptor binding
Biological Process: focal adhesion formation; positive regulation of glucose import; cellular response to insulin stimulus; muscle contraction; positive regulation of signal transduction; cell-matrix adhesion; positive regulation of glycogen biosynthetic process; stress fiber formation; insulin receptor signaling pathway; positive regulation of lipid biosynthetic process; glucose transport
Research Articles on SORBS1
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Product Notes
The SORBS1 sorbs1 (Catalog #AAA1753108) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SORBS1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SORBS1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Flow Cytometry (FC/FACS), Direct ELISA (EIA). WB: 0.25-0.5ug/ml (Human) IHC-P (Embedded Section): 0.5-1ug/ml (Human) FC/FACS: 1-3ug/1x106 cells (Human) Direct ELISA: 0.1-0.5ug/ml (Human) Tested Species: In-house tested species with positive results. Researchers should empirically determine the suitability of the SORBS1 sorbs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SORBS1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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