Rabbit anti-Rat Somatostatin Receptor Type 1 (SSTR1) Polyclonal Antibody | anti-SSTR1 antibody

Anti-Somatostatin Receptor Type 1 (Extracellular) (SSTR1) Antibody

Cat. Num. AAA4157642

• Gene Names: SSTR1; SS1R; SS1-R; SRIF-2; SS-1-R
• Reactivity: Rat
• Applications: Western Blot
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: Somatostatin Receptor Type 1 (SSTR1); Polyclonal Antibody; Anti-Somatostatin Receptor Type 1 (Extracellular) (SSTR1) Antibody; Somatostatin Receptor Type 1; anti-SSTR1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 391

• Applicable Applications for anti-SSTR1 antibody: Western Blot (WB)
• Immunogen: Peptide CSRGPGSGAADGMEE (corresponding to residues 26-40 of rat somatostatin receptor type 1 (Accession# P28646).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-SSTR1 antibody

Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain it acts as a neurotransmitter in both stimulatory and inhibitory manner.1, 2 Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4 and SSTR5) which are encoded by five genes.1, 2 Expression of the different receptors is developmentally regulated in a time and tissue-specific manner.2 Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids and breast tumors.3 Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in in vivo imaging of tumors that are positive to somatostatin receptors.4

NCBI and Uniprot Product Information

• NCBI GI #: 4557857
• NCBI GeneID: 6751
• NCBI GenBank Nucleotide #: NP_001040.1
• UniProt Accession #: P30872
• NCBI Official Full Name: somatostatin receptor type 1
• NCBI Official Synonym Full Names: somatostatin receptor 1
• NCBI Official Symbol: SSTR1
• NCBI Official Synonym Symbols: SS1R; SS1-R; SRIF-2; SS-1-R
• NCBI Protein Information: somatostatin receptor type 1
• UniProt Protein Name: Somatostatin receptor type 1
• Protein Family: Somatostatin receptor
• UniProt Gene Name: SSTR1
• UniProt Synonym Gene Names: SS-1-R; SS1-R; SS1R
• UniProt Entry Name: SSR1_HUMAN

NCBI Description

Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

Uniprot Description

SSTR1: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Belongs to the G-protein coupled receptor 1 family. Interacts with SKB1.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; Cell cycle regulation; GPCR, family 1

Chromosomal Location of Human Ortholog: 14q13

Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: neuropeptide binding; somatostatin receptor activity

Biological Process: glutamate signaling pathway; response to starvation; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; cell surface receptor linked signal transduction; cell-cell signaling; neuropeptide signaling pathway; forebrain development; digestion; cerebellum development; spermatogenesis; response to nutrient