Rabbit Somatostatin Polyclonal Antibody | anti-SST antibody

Anti-Somatostatin Antibody, Rabbit Polyclonal

Cat. Num. AAA8102861

• Gene Names: SST; SMST
• Reactivity: Human; Predicted to React with: Mouse, Rat, Cynomolgus (Species predicted to react based on 100% sequence homology)
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: Somatostatin; Polyclonal Antibody; Anti-Somatostatin Antibody; Rabbit Polyclonal; SST Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-SMST Antibody; anti-SST antibody

• Host: Rabbit
• Reactivity: Human; Predicted to React with: Mouse, Rat, Cynomolgus (Species predicted to react based on 100% sequence homology)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human Somatostatin
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-SST antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the center region of the Human SST
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human SST, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human SST in human pancreas with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-SST antibody

Somatostatin (SST) is a cyclic peptide that is understood to inhibit the release of hormones and neurotransmitters from a variety of cells by binding to one of five canonical G protein-coupled SST receptors (SSTR1 to SSTR5). Somatostatin (SST) is an inhibitor of the release of somatotropin, glucagon, insulin, gastrointestinal hormones, and other secretory proteins (1). SST is also known as somatotropin release-inhibiting factor (SRIF). SST is a cyclic polypeptide with two biologically active isoforms, SRIF-14 and SRIF-28, of 14 and 28 amino acids, respectively. SST negatively regulates cell proliferation and the release of multiple hormones via activation of its cognate receptors. A variety of SST analogs, some with high affinity and selectivity of receptor subtypes, have been synthesized and developed.

References

Sun L, et al. (2016) Somatostatin and its analogs. Curr Drug Targets 17 (5): 529-537.Solarski M, et al. (2019) The human brain somatostatin interactome: Sst binds selectively to p-type family atpases. PLoS One 14 (5): e0217392.Leung K. (2009) 64 Cu-4, 11-Bis(carboxymethyl)-1, 4, 8, 11-tetraazabicyclo[6.6.2]hexadecane-D-Phe-cyclo(Cys-Tyr-D-Trp-Lys-Thr-Cys)-Thr(OH).

NCBI and Uniprot Product Information

• NCBI GI #: 4507243
• NCBI GeneID: 6750
• NCBI Accession #: NP_001039.1
• NCBI GenBank Nucleotide #: NM_001048.3
• UniProt Accession #: P61278; P01166; B2R5G3
• Molecular Weight: 12,736 Da
• NCBI Official Full Name: somatostatin preproprotein
• NCBI Official Synonym Full Names: somatostatin
• NCBI Official Symbol: SST
• NCBI Official Synonym Symbols: SMST
• NCBI Protein Information: somatostatin; growth hormone release-inhibiting factor; prepro-somatostatin; somatostatin-14; somatostatin-28
• UniProt Protein Name: Somatostatin
• Protein Family: Somatostatin
• UniProt Gene Name: SST
• UniProt Entry Name: SMS_HUMAN

NCBI Description

The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]

Uniprot Description

SST: Somatostatin inhibits the release of somatotropin. Belongs to the somatostatin family.

Protein type: Secreted, signal peptide; Secreted; Hormone

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: extracellular space; cell soma; extracellular region

Molecular Function: hormone activity

Biological Process: response to drug; induction of apoptosis by hormones; response to amino acid stimulus; regulation of cell migration; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; synaptic transmission; hyperosmotic response; cell surface receptor linked signal transduction; cell-cell signaling; response to heat; response to steroid hormone stimulus; digestion; response to nutrient