Rabbit Somatostatin Polyclonal Antibody | anti-SST antibody

Somatostatin Antibody

Cat. Num. AAA9612002

• Gene Names: SST; SMST
• Reactivity: Human, Mouse, Rat; Predicted Reactivity: Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(88%), Xenopus(88%)
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: Somatostatin; Polyclonal Antibody; Somatostatin Antibody; Growth hormone release inhibiting factor; Growth hormone release-inhibiting factor; Prepro somatostatin; SMS_HUMAN; SMST; Somatostatin 14; Somatostatin 28; Somatostatin-14; SST; anti-SST antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat; Predicted Reactivity: Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(88%), Xenopus(88%)
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Somatostatin Antibody detects endogenous levels of total Somatostatin.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 116

• Applicable Applications for anti-SST antibody: ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; ELISA(peptide): 1:20,000-1:40,000
• Immunogen: A synthesized peptide derived from human Somatostatin, corresponding to a region within the internal amino acids.
• Fragment: Fab fragment
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from various samples, using Somatostatin Antibody.Lane 1: Myeloma cells, treated with blocking peptide;Lane 2: Myeloma cells;Lane 3: EC304 cells.Observed bands: 18,25 kDa.)

Related Product Information for anti-SST antibody

Function: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476).

Post Translational Modifications: C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.

Subcellular Location: Secreted.

Similarity: Belongs to the somatostatin family.

NCBI and Uniprot Product Information

• NCBI GI #: 4507243
• NCBI GeneID: 6750
• NCBI Accession #: NP_001039.1
• NCBI GenBank Nucleotide #: NP_001039.1
• UniProt Accession #: P61278
• Molecular Weight: Observed Molecular Weight: (Observed)12kD, 18kD, 25kD.; Predicted Molecular Weight: (Calculated)13kDa.
• NCBI Official Full Name: somatostatin preproprotein
• NCBI Official Synonym Full Names: somatostatin
• NCBI Official Symbol: SST
• NCBI Official Synonym Symbols: SMST
• NCBI Protein Information: somatostatin
• UniProt Protein Name: Somatostatin
• Protein Family: Somatostatin
• UniProt Gene Name: SST
• UniProt Entry Name: SMS_HUMAN

NCBI Description

The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]

Uniprot Description

SST: Somatostatin inhibits the release of somatotropin. Belongs to the somatostatin family.

Protein type: Secreted, signal peptide; Secreted; Hormone

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: extracellular space; cell soma; extracellular region

Molecular Function: hormone activity

Biological Process: response to drug; induction of apoptosis by hormones; response to amino acid stimulus; regulation of cell migration; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; synaptic transmission; hyperosmotic response; cell surface receptor linked signal transduction; cell-cell signaling; response to heat; response to steroid hormone stimulus; digestion; response to nutrient